Procoagulant constituents from Cordyceps militaris
Cordyceps militaris, belongs to Clavicipitaceae family, was investigated for its chemical compounds, and six compounds were isolated and purified by silica gel column chromatography, Sephadex LH-20 and recrystallization, and their structures were elucidated by spectral techniques and physicochemical...
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| Format: | Article |
| Language: | English |
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Tsinghua University Press
2018-12-01
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| Series: | Food Science and Human Wellness |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213453018301411 |
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| author | Juanjuan Zhang Wei Zhang Zhenhua Yin Changqin Li Wenyi Kang |
| author_facet | Juanjuan Zhang Wei Zhang Zhenhua Yin Changqin Li Wenyi Kang |
| author_sort | Juanjuan Zhang |
| collection | DOAJ |
| description | Cordyceps militaris, belongs to Clavicipitaceae family, was investigated for its chemical compounds, and six compounds were isolated and purified by silica gel column chromatography, Sephadex LH-20 and recrystallization, and their structures were elucidated by spectral techniques and physicochemical properties as ergosterol (1), adenosine (2), cordycepin (3), ergosterol peroxide (4), tetracosanoic acid 2,3-dihydroxypropylester (5), mannitol (6). Procoagulant activity was screened by assaying the activated partial thromboplastin time (APTT), prothrombin time (PT), thrombin time (TT) and fibrinogen (FIB) in vitro. The results indicated that ergosterol, adenosine, cordycepin, ergosterol peroxide and mannitol showed strong procoagulant activity. Keywords: Cordyceps militaris, Chemical component, Procoagulant activity, Ergosterol |
| format | Article |
| id | doaj-art-66657a4e06a0417589a69a5005966642 |
| institution | Kabale University |
| issn | 2213-4530 |
| language | English |
| publishDate | 2018-12-01 |
| publisher | Tsinghua University Press |
| record_format | Article |
| series | Food Science and Human Wellness |
| spelling | doaj-art-66657a4e06a0417589a69a50059666422025-02-03T04:00:52ZengTsinghua University PressFood Science and Human Wellness2213-45302018-12-0174282286Procoagulant constituents from Cordyceps militarisJuanjuan Zhang0Wei Zhang1Zhenhua Yin2Changqin Li3Wenyi Kang4Huanghe Science and Technology College, Zhengzhou Key Laboratory of Medicinal Research, Zhengzhou, 450063, ChinaHuanghe Science and Technology College, Zhengzhou Key Laboratory of Medicinal Research, Zhengzhou, 450063, ChinaHuanghe Science and Technology College, Zhengzhou Key Laboratory of Medicinal Research, Zhengzhou, 450063, ChinaInstitute of Chinese Materia Medica, Henan University, Kaifeng, 475004, China; Corresponding authors at: Institute of Chinese Materia Medica, Henan University, Kaifeng, 475004, Henan, China.Huanghe Science and Technology College, Zhengzhou Key Laboratory of Medicinal Research, Zhengzhou, 450063, China; Institute of Chinese Materia Medica, Henan University, Kaifeng, 475004, China; Corresponding authors at: Institute of Chinese Materia Medica, Henan University, Kaifeng, 475004, Henan, China.Cordyceps militaris, belongs to Clavicipitaceae family, was investigated for its chemical compounds, and six compounds were isolated and purified by silica gel column chromatography, Sephadex LH-20 and recrystallization, and their structures were elucidated by spectral techniques and physicochemical properties as ergosterol (1), adenosine (2), cordycepin (3), ergosterol peroxide (4), tetracosanoic acid 2,3-dihydroxypropylester (5), mannitol (6). Procoagulant activity was screened by assaying the activated partial thromboplastin time (APTT), prothrombin time (PT), thrombin time (TT) and fibrinogen (FIB) in vitro. The results indicated that ergosterol, adenosine, cordycepin, ergosterol peroxide and mannitol showed strong procoagulant activity. Keywords: Cordyceps militaris, Chemical component, Procoagulant activity, Ergosterolhttp://www.sciencedirect.com/science/article/pii/S2213453018301411 |
| spellingShingle | Juanjuan Zhang Wei Zhang Zhenhua Yin Changqin Li Wenyi Kang Procoagulant constituents from Cordyceps militaris Food Science and Human Wellness |
| title | Procoagulant constituents from Cordyceps militaris |
| title_full | Procoagulant constituents from Cordyceps militaris |
| title_fullStr | Procoagulant constituents from Cordyceps militaris |
| title_full_unstemmed | Procoagulant constituents from Cordyceps militaris |
| title_short | Procoagulant constituents from Cordyceps militaris |
| title_sort | procoagulant constituents from cordyceps militaris |
| url | http://www.sciencedirect.com/science/article/pii/S2213453018301411 |
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