Upregulation of GSTP1 mediated by chimeric TFE3 promotes TFE3-tRCC progression by targeting JNK signaling pathway

Upregulation of GSTP1 mediated by chimeric TFE3 promotes TFE3-tRCC progression by targeting JNK signaling pathway

Abstract Background TFE3-translocation renal cell carcinoma (TFE3-tRCC), a distinct subtype of kidney cancer characterized by Xp11.2 translocations, involving TFE3 fusion with various partner genes, lacks effective treatments and prognostic biomarkers for advanced stages. This study aimed to unravel...

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Bibliographic Details
Main Authors: Weixu Chen, Mengtong Wu, Lin Du, Changhua Fang, Hao Wang, Wendi Wang, Chengwei Zhang, Hongqian Guo, Gutian Zhang
Format: Article
Language:English
Published: BMC 2024-12-01
Series:World Journal of Surgical Oncology
Subjects:
TFE3-tRCC
GSTP1
ASPL-TFE3
JNK signaling pathway
Ezatiostat
Online Access:https://doi.org/10.1186/s12957-024-03633-w
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