The Helicobacter pylori orphan ATTAAT-specific methyltransferase M.Hpy99XIX plays a central role in the coordinated regulation of genes involved in iron metabolism

The Helicobacter pylori orphan ATTAAT-specific methyltransferase M.Hpy99XIX plays a central role in the coordinated regulation of genes involved in iron metabolism

ABSTRACT Helicobacter pylori genomes contain a large and variable portfolio of methyltransferases (MTases), creating a highly diverse methylome. Here, we characterize a highly conserved ATTAAT-specific MTase, M.Hpy99XIX (H. pylori strain J99, alternative designations in other strains, M.HpyAVII and...

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Bibliographic Details
Main Authors: Wilhelm Gottschall, Florent Ailloud, Christine Josenhans, Sebastian Suerbaum
Format: Article
Language:English
Published: American Society for Microbiology 2025-07-01
Series:mBio
Subjects:
Helicobacter pylori
DNA methylation
transcriptome
bacterial epigenetics
promoters
genomics
Online Access:https://journals.asm.org/doi/10.1128/mbio.01209-25
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