Potential Reduction in Adverse Events and Cost with Novel Anticoagulants among Patients with Acute Limb Ischemia
Background. Acute limb ischemia (ALI) is associated with significant morbidity and mortality. Novel anticoagulants reduce adverse events among patients with peripheral artery disease, though the potential effect of these therapies is unclear in patients with ALI. The present study thus sought to eva...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2022-01-01
|
| Series: | International Journal of Vascular Medicine |
| Online Access: | http://dx.doi.org/10.1155/2022/3786815 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850158856579055616 |
|---|---|
| author | Scott Freeman Piper Williams Anna E. Barón Mary E. Plomondon Stephen W. Waldo |
| author_facet | Scott Freeman Piper Williams Anna E. Barón Mary E. Plomondon Stephen W. Waldo |
| author_sort | Scott Freeman |
| collection | DOAJ |
| description | Background. Acute limb ischemia (ALI) is associated with significant morbidity and mortality. Novel anticoagulants reduce adverse events among patients with peripheral artery disease, though the potential effect of these therapies is unclear in patients with ALI. The present study thus sought to evaluate the potential clinical benefit of universal application of novel anticoagulants to a high-risk population of patients with ALI. Methods. In this retrospective cohort study, we identified patients diagnosed with ALI in the Veterans Affairs Healthcare System between 2015 and 2016. We then calculated the incidence of adverse cardiovascular events (death/stroke/myocardial infarction/amputation/repeat intervention) as if they were treated with rivaroxaban using published data. Further, we calculated the cost to treat a Veteran diagnosed with one of these outcomes, and the potential savings had patients been universally treated with novel anticoagulants. Results. We identified 286 patients that presented with lower extremity ALI and were not treated with anticoagulation. Potential treatment of these patients with rivaroxaban resulted in significantly fewer adverse events, with an 11.9% reduction in cases at 21 months (95% CI: 5.5-17.8%) and a 13.4% reduction in cases at 47 months (95% CI: 5.6-20.5%). This corresponded to significant decreases in healthcare spending for patients with ALI who were treated with rivaroxaban. Conclusions. Among patients with ALI, treatment with rivaroxaban could result in a significant reduction in adverse cardiovascular events. The reduction in events would in turn lead to significant decreases in healthcare spending for this population. |
| format | Article |
| id | doaj-art-665fa6b9b0224f9d8f97198010053ea5 |
| institution | OA Journals |
| issn | 2090-2832 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Vascular Medicine |
| spelling | doaj-art-665fa6b9b0224f9d8f97198010053ea52025-08-20T02:23:45ZengWileyInternational Journal of Vascular Medicine2090-28322022-01-01202210.1155/2022/3786815Potential Reduction in Adverse Events and Cost with Novel Anticoagulants among Patients with Acute Limb IschemiaScott Freeman0Piper Williams1Anna E. Barón2Mary E. Plomondon3Stephen W. Waldo4Department of MedicineDepartment of MedicineDepartment of Biostatistics and InformaticsVHA Office of Quality and Patient SafetyDepartment of MedicineBackground. Acute limb ischemia (ALI) is associated with significant morbidity and mortality. Novel anticoagulants reduce adverse events among patients with peripheral artery disease, though the potential effect of these therapies is unclear in patients with ALI. The present study thus sought to evaluate the potential clinical benefit of universal application of novel anticoagulants to a high-risk population of patients with ALI. Methods. In this retrospective cohort study, we identified patients diagnosed with ALI in the Veterans Affairs Healthcare System between 2015 and 2016. We then calculated the incidence of adverse cardiovascular events (death/stroke/myocardial infarction/amputation/repeat intervention) as if they were treated with rivaroxaban using published data. Further, we calculated the cost to treat a Veteran diagnosed with one of these outcomes, and the potential savings had patients been universally treated with novel anticoagulants. Results. We identified 286 patients that presented with lower extremity ALI and were not treated with anticoagulation. Potential treatment of these patients with rivaroxaban resulted in significantly fewer adverse events, with an 11.9% reduction in cases at 21 months (95% CI: 5.5-17.8%) and a 13.4% reduction in cases at 47 months (95% CI: 5.6-20.5%). This corresponded to significant decreases in healthcare spending for patients with ALI who were treated with rivaroxaban. Conclusions. Among patients with ALI, treatment with rivaroxaban could result in a significant reduction in adverse cardiovascular events. The reduction in events would in turn lead to significant decreases in healthcare spending for this population.http://dx.doi.org/10.1155/2022/3786815 |
| spellingShingle | Scott Freeman Piper Williams Anna E. Barón Mary E. Plomondon Stephen W. Waldo Potential Reduction in Adverse Events and Cost with Novel Anticoagulants among Patients with Acute Limb Ischemia International Journal of Vascular Medicine |
| title | Potential Reduction in Adverse Events and Cost with Novel Anticoagulants among Patients with Acute Limb Ischemia |
| title_full | Potential Reduction in Adverse Events and Cost with Novel Anticoagulants among Patients with Acute Limb Ischemia |
| title_fullStr | Potential Reduction in Adverse Events and Cost with Novel Anticoagulants among Patients with Acute Limb Ischemia |
| title_full_unstemmed | Potential Reduction in Adverse Events and Cost with Novel Anticoagulants among Patients with Acute Limb Ischemia |
| title_short | Potential Reduction in Adverse Events and Cost with Novel Anticoagulants among Patients with Acute Limb Ischemia |
| title_sort | potential reduction in adverse events and cost with novel anticoagulants among patients with acute limb ischemia |
| url | http://dx.doi.org/10.1155/2022/3786815 |
| work_keys_str_mv | AT scottfreeman potentialreductioninadverseeventsandcostwithnovelanticoagulantsamongpatientswithacutelimbischemia AT piperwilliams potentialreductioninadverseeventsandcostwithnovelanticoagulantsamongpatientswithacutelimbischemia AT annaebaron potentialreductioninadverseeventsandcostwithnovelanticoagulantsamongpatientswithacutelimbischemia AT maryeplomondon potentialreductioninadverseeventsandcostwithnovelanticoagulantsamongpatientswithacutelimbischemia AT stephenwwaldo potentialreductioninadverseeventsandcostwithnovelanticoagulantsamongpatientswithacutelimbischemia |