Amblyostatin-1, the first salivary cystatin with host immunomodulatory and anti-inflammatory properties from the Neotropical tick Amblyomma sculptum, vector of Brazilian spotted fever

Amblyostatin-1, the first salivary cystatin with host immunomodulatory and anti-inflammatory properties from the Neotropical tick Amblyomma sculptum, vector of Brazilian spotted fever

IntroductionThe Neotropical tick Amblyomma sculptum is the primary vector of Rickettsia rickettsii, the causative agent of Brazilian spotted fever, a disease associated with high fatality rates. Tick saliva, a complex mixture of bioactive molecules essential for successful blood feeding, facilitates...

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Main Authors: Wilson Santos Molari, Mohamed Amine Jmel, Josiane Betim Assis, Alan Frazão-Silva, Júlia Moura Bernardi, Gretta Huamanrayme, José María Medina, Eliane Esteves, Solange Cristina Antão, Gabriel Cerqueira Alves Costa, Aparecida Sadae Tanaka, Andréa Cristina Fogaça, Zdenek Franta, Lucas Tirloni, Michalis Kotsyfakis, Anderson Sá-Nunes
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Immunology
Subjects:
Amblyostatin-1
Amblyomma sculptum
immunomodulation
inflammation
tick-host interaction
tick saliva
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1585703/full
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