Molecular disorders of erythrocyte and platelet membranes in vascular complications of type 1 diabetes mellitus
The aim of the present study was to establish the role of disturbances of structural-functional properties of erythrocyte and platelet membranes in mechanisms of development and progression of vascular complications of type 1 diabetes. The subjects were 92 patients (48 men and 44 women, aged from 18...
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| Format: | Article |
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Siberian State Medical University (Tomsk)
2006-12-01
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| Series: | Бюллетень сибирской медицины |
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| Online Access: | https://bulletin.ssmu.ru/jour/article/view/3116 |
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| author | Ye. B. Kravets N. V. Ryazantseva N. M. Yakovleva V. N. Butusova O. M. Choudakova E. V. Saprykina |
| author_facet | Ye. B. Kravets N. V. Ryazantseva N. M. Yakovleva V. N. Butusova O. M. Choudakova E. V. Saprykina |
| author_sort | Ye. B. Kravets |
| collection | DOAJ |
| description | The aim of the present study was to establish the role of disturbances of structural-functional properties of erythrocyte and platelet membranes in mechanisms of development and progression of vascular complications of type 1 diabetes. The subjects were 92 patients (48 men and 44 women, aged from 18 to 55) affected by type 1 diabetes in different stages of diabetic retinopathy and diabetic nephropathy. The results have shown the significant structural and functional changes of red blood cells and platelet membranes in type 1 diabetes mellitus. These changes (increase of microviscosity of lipid phase, inhibition of Na+,K+-АТPase activity) correlated with the degree of expression of vascular complications. Since the rheologic properties of blood cells, particularly its microrheologic features, are determined by the membrane status, the detection of changes in the molecular organization of erythrocyte and platelet membranes can be consider as a pathogenic link of diabetic microangiopathies. |
| format | Article |
| id | doaj-art-665a0b45bc234d4d801feac0625279c2 |
| institution | Kabale University |
| issn | 1682-0363 1819-3684 |
| language | English |
| publishDate | 2006-12-01 |
| publisher | Siberian State Medical University (Tomsk) |
| record_format | Article |
| series | Бюллетень сибирской медицины |
| spelling | doaj-art-665a0b45bc234d4d801feac0625279c22025-08-20T03:38:26ZengSiberian State Medical University (Tomsk)Бюллетень сибирской медицины1682-03631819-36842006-12-0154334110.20538/1682-0363-2006-4-33-411774Molecular disorders of erythrocyte and platelet membranes in vascular complications of type 1 diabetes mellitusYe. B. Kravets0N. V. Ryazantseva1N. M. Yakovleva2V. N. Butusova3O. M. Choudakova4E. V. Saprykina5Сибирский государственный медицинский университетСибирский государственный медицинский университетСибирский государственный медицинский университетСибирский государственный медицинский университетСибирский государственный медицинский университетСибирский государственный медицинский университетThe aim of the present study was to establish the role of disturbances of structural-functional properties of erythrocyte and platelet membranes in mechanisms of development and progression of vascular complications of type 1 diabetes. The subjects were 92 patients (48 men and 44 women, aged from 18 to 55) affected by type 1 diabetes in different stages of diabetic retinopathy and diabetic nephropathy. The results have shown the significant structural and functional changes of red blood cells and platelet membranes in type 1 diabetes mellitus. These changes (increase of microviscosity of lipid phase, inhibition of Na+,K+-АТPase activity) correlated with the degree of expression of vascular complications. Since the rheologic properties of blood cells, particularly its microrheologic features, are determined by the membrane status, the detection of changes in the molecular organization of erythrocyte and platelet membranes can be consider as a pathogenic link of diabetic microangiopathies.https://bulletin.ssmu.ru/jour/article/view/3116сахарный диабет типа 1диабетические ангиопатииэритроциттромбоцитмембранафлюоресцентное зондированиеактивность na<sup>+</sup>k<sup>+</sup>-атфазыагрегацияtype 1 diabetes mellitusdiabetic angiopathyerythrocyteplateletmembranefluorescent probena<sup>+</sup>k<sup>+</sup>-atpase activityaggregation |
| spellingShingle | Ye. B. Kravets N. V. Ryazantseva N. M. Yakovleva V. N. Butusova O. M. Choudakova E. V. Saprykina Molecular disorders of erythrocyte and platelet membranes in vascular complications of type 1 diabetes mellitus Бюллетень сибирской медицины сахарный диабет типа 1 диабетические ангиопатии эритроцит тромбоцит мембрана флюоресцентное зондирование активность na<sup>+</sup> k<sup>+</sup>-атфазы агрегация type 1 diabetes mellitus diabetic angiopathy erythrocyte platelet membrane fluorescent probe na<sup>+</sup> k<sup>+</sup>-atpase activity aggregation |
| title | Molecular disorders of erythrocyte and platelet membranes in vascular complications of type 1 diabetes mellitus |
| title_full | Molecular disorders of erythrocyte and platelet membranes in vascular complications of type 1 diabetes mellitus |
| title_fullStr | Molecular disorders of erythrocyte and platelet membranes in vascular complications of type 1 diabetes mellitus |
| title_full_unstemmed | Molecular disorders of erythrocyte and platelet membranes in vascular complications of type 1 diabetes mellitus |
| title_short | Molecular disorders of erythrocyte and platelet membranes in vascular complications of type 1 diabetes mellitus |
| title_sort | molecular disorders of erythrocyte and platelet membranes in vascular complications of type 1 diabetes mellitus |
| topic | сахарный диабет типа 1 диабетические ангиопатии эритроцит тромбоцит мембрана флюоресцентное зондирование активность na<sup>+</sup> k<sup>+</sup>-атфазы агрегация type 1 diabetes mellitus diabetic angiopathy erythrocyte platelet membrane fluorescent probe na<sup>+</sup> k<sup>+</sup>-atpase activity aggregation |
| url | https://bulletin.ssmu.ru/jour/article/view/3116 |
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