Mechanism of action behind the pain-relief effects of extracellular vesicles in microfragmented adipose tissue: an in vitro and in vivo study

Mechanism of action behind the pain-relief effects of extracellular vesicles in microfragmented adipose tissue: an in vitro and in vivo study

Abstract Background Trapeziometacarpal osteoarthritis (TMC OA) is a prevalent and debilitating condition that impairs hand functionality and reduces quality of life. Current treatments including conservative measures such as splinting and anti-inflammatory medications, as well as surgical interventi...

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Main Authors: Francesco De Francesco, Letizia Ferroni, Ilaria Zanolla, Lucia Sileo, Maria Pia Cavaleri, Mario Fordellone, Letizia Senesi, Anna Maria Monachino, Elena Tremoli, Ilenia Pia Cappucci, Eduardo Maria Sommella, Massimo Bonora, Alfredo Ronca, Ugo D’Amora, Noemi De Cesare, Luca Lovatti, Michele Riccio, Ali Mobasheri, Paolo Pinton, Barbara Zavan
Format: Article
Language:English
Published: BMC 2025-08-01
Series:Journal of Translational Medicine
Subjects:
Adipose stem cells
Non-enzymatic method
Rigenera protocol
Trapeziometacarpal arthritis
Microfragmented adipose tissue; extracellular vesicles
Online Access:https://doi.org/10.1186/s12967-025-06930-4
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