Inositols in Insulin Signaling and Glucose Metabolism
In the past decades, both the importance of inositol for human health and the complex interaction between glucose and inositol have been the subject of increasing consideration. Glucose has been shown to interfere with cellular transmembrane transport of inositol, inhibiting, among others, its intes...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2018/1968450 |
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| author | Arturo Bevilacqua Mariano Bizzarri |
| author_facet | Arturo Bevilacqua Mariano Bizzarri |
| author_sort | Arturo Bevilacqua |
| collection | DOAJ |
| description | In the past decades, both the importance of inositol for human health and the complex interaction between glucose and inositol have been the subject of increasing consideration. Glucose has been shown to interfere with cellular transmembrane transport of inositol, inhibiting, among others, its intestinal absorption. Moreover, intracellular glucose is required for de novo biosynthesis of inositol through the inositol-3-phosphate synthase 1 pathway, while a few glucose-related metabolites, like sorbitol, reduce intracellular levels of inositol. Furthermore, inositol, via its major isomers myo-inositol and D-chiro-inositol, and probably some of its phosphate intermediate metabolites and correlated enzymes (like inositol hexakisphosphate kinase) participate in both insulin signaling and glucose metabolism by influencing distinct pathways. Indeed, clinical data support the beneficial effects exerted by inositol by reducing glycaemia levels and hyperinsulinemia and buffering negative effects of sustained insulin stimulation upon the adipose tissue and the endocrine system. Due to these multiple effects, myoIns has become a reliable treatment option, as opposed to hormonal stimulation, for insulin-resistant PCOS patients. |
| format | Article |
| id | doaj-art-6654e820a2cd4d31b9154aa5f7966e2c |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-6654e820a2cd4d31b9154aa5f7966e2c2025-02-03T01:11:30ZengWileyInternational Journal of Endocrinology1687-83371687-83452018-01-01201810.1155/2018/19684501968450Inositols in Insulin Signaling and Glucose MetabolismArturo Bevilacqua0Mariano Bizzarri1Department of Dynamic and Clinical Psychology, Sapienza University of Rome, via dei Marsi 78, 00185 Rome, ItalyDepartment of Experimental Medicine, Systems Biology Group Lab, Sapienza University of Rome, via A. Scarpa 16, 00161 Rome, ItalyIn the past decades, both the importance of inositol for human health and the complex interaction between glucose and inositol have been the subject of increasing consideration. Glucose has been shown to interfere with cellular transmembrane transport of inositol, inhibiting, among others, its intestinal absorption. Moreover, intracellular glucose is required for de novo biosynthesis of inositol through the inositol-3-phosphate synthase 1 pathway, while a few glucose-related metabolites, like sorbitol, reduce intracellular levels of inositol. Furthermore, inositol, via its major isomers myo-inositol and D-chiro-inositol, and probably some of its phosphate intermediate metabolites and correlated enzymes (like inositol hexakisphosphate kinase) participate in both insulin signaling and glucose metabolism by influencing distinct pathways. Indeed, clinical data support the beneficial effects exerted by inositol by reducing glycaemia levels and hyperinsulinemia and buffering negative effects of sustained insulin stimulation upon the adipose tissue and the endocrine system. Due to these multiple effects, myoIns has become a reliable treatment option, as opposed to hormonal stimulation, for insulin-resistant PCOS patients.http://dx.doi.org/10.1155/2018/1968450 |
| spellingShingle | Arturo Bevilacqua Mariano Bizzarri Inositols in Insulin Signaling and Glucose Metabolism International Journal of Endocrinology |
| title | Inositols in Insulin Signaling and Glucose Metabolism |
| title_full | Inositols in Insulin Signaling and Glucose Metabolism |
| title_fullStr | Inositols in Insulin Signaling and Glucose Metabolism |
| title_full_unstemmed | Inositols in Insulin Signaling and Glucose Metabolism |
| title_short | Inositols in Insulin Signaling and Glucose Metabolism |
| title_sort | inositols in insulin signaling and glucose metabolism |
| url | http://dx.doi.org/10.1155/2018/1968450 |
| work_keys_str_mv | AT arturobevilacqua inositolsininsulinsignalingandglucosemetabolism AT marianobizzarri inositolsininsulinsignalingandglucosemetabolism |