Research advances on the role of Runx2-related miRNAs in vascular calcification of chronic kidney disease
Vascular calcification （VC） is a major cause of cardiovascular mortality in patients with chronic kidney disease （CKD）. Current studies suggest that VC of CKD is not simply an ectopic deposition of calcium phosphate crystals in vascular wall. Formation of calcification has a similar mechanism to bon...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | zho |
| Published: |
Editorial Department of Journal of Clinical Nephrology
2022-11-01
|
| Series: | Linchuang shenzangbing zazhi |
| Subjects: | |
| Online Access: | http://www.lcszb.com/thesisDetails#10.3969/j.issn.1671-2390.2022.11.012 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850186964327727104 |
|---|---|
| author | Lu Yang-yang Bai Ya-ling Xu Jin-sheng |
| author_facet | Lu Yang-yang Bai Ya-ling Xu Jin-sheng |
| author_sort | Lu Yang-yang |
| collection | DOAJ |
| description | Vascular calcification （VC） is a major cause of cardiovascular mortality in patients with chronic kidney disease （CKD）. Current studies suggest that VC of CKD is not simply an ectopic deposition of calcium phosphate crystals in vascular wall. Formation of calcification has a similar mechanism to bone mineralization and smooth muscle cells play a key role in VC. Sufficient evidence suggested that Runx2 is an essential regulator of osteogenic differentiation and calcification in vascular smooth muscle cells. In recent years， multiple microRNAs have been identified as key regulators for differentiation of vascular smooth muscle cell， phenotypic switching， proliferation， apoptosis， cytokine production and matrix deposition during VC. This review focused upon the role of relevant microRNAs regulating Runx2 expression in osteogenic differentiation of smooth muscle cells. Since the exact mechanism of VC has remained largely elusive， a better understanding of microRNA involvement in VC may help to design novel therapies for VC. |
| format | Article |
| id | doaj-art-664c6e28a5714cdea25afeb48a9dde2a |
| institution | OA Journals |
| issn | 1671-2390 |
| language | zho |
| publishDate | 2022-11-01 |
| publisher | Editorial Department of Journal of Clinical Nephrology |
| record_format | Article |
| series | Linchuang shenzangbing zazhi |
| spelling | doaj-art-664c6e28a5714cdea25afeb48a9dde2a2025-08-20T02:16:13ZzhoEditorial Department of Journal of Clinical NephrologyLinchuang shenzangbing zazhi1671-23902022-11-012295295832859657Research advances on the role of Runx2-related miRNAs in vascular calcification of chronic kidney diseaseLu Yang-yangBai Ya-lingXu Jin-shengVascular calcification （VC） is a major cause of cardiovascular mortality in patients with chronic kidney disease （CKD）. Current studies suggest that VC of CKD is not simply an ectopic deposition of calcium phosphate crystals in vascular wall. Formation of calcification has a similar mechanism to bone mineralization and smooth muscle cells play a key role in VC. Sufficient evidence suggested that Runx2 is an essential regulator of osteogenic differentiation and calcification in vascular smooth muscle cells. In recent years， multiple microRNAs have been identified as key regulators for differentiation of vascular smooth muscle cell， phenotypic switching， proliferation， apoptosis， cytokine production and matrix deposition during VC. This review focused upon the role of relevant microRNAs regulating Runx2 expression in osteogenic differentiation of smooth muscle cells. Since the exact mechanism of VC has remained largely elusive， a better understanding of microRNA involvement in VC may help to design novel therapies for VC.http://www.lcszb.com/thesisDetails#10.3969/j.issn.1671-2390.2022.11.012Smooth muscle cellVascular calcificationMicroRNAsRunt-related transcription factor 2 |
| spellingShingle | Lu Yang-yang Bai Ya-ling Xu Jin-sheng Research advances on the role of Runx2-related miRNAs in vascular calcification of chronic kidney disease Linchuang shenzangbing zazhi Smooth muscle cell Vascular calcification MicroRNAs Runt-related transcription factor 2 |
| title | Research advances on the role of Runx2-related miRNAs in vascular calcification of chronic kidney disease |
| title_full | Research advances on the role of Runx2-related miRNAs in vascular calcification of chronic kidney disease |
| title_fullStr | Research advances on the role of Runx2-related miRNAs in vascular calcification of chronic kidney disease |
| title_full_unstemmed | Research advances on the role of Runx2-related miRNAs in vascular calcification of chronic kidney disease |
| title_short | Research advances on the role of Runx2-related miRNAs in vascular calcification of chronic kidney disease |
| title_sort | research advances on the role of runx2 related mirnas in vascular calcification of chronic kidney disease |
| topic | Smooth muscle cell Vascular calcification MicroRNAs Runt-related transcription factor 2 |
| url | http://www.lcszb.com/thesisDetails#10.3969/j.issn.1671-2390.2022.11.012 |
| work_keys_str_mv | AT luyangyang researchadvancesontheroleofrunx2relatedmirnasinvascularcalcificationofchronickidneydisease AT baiyaling researchadvancesontheroleofrunx2relatedmirnasinvascularcalcificationofchronickidneydisease AT xujinsheng researchadvancesontheroleofrunx2relatedmirnasinvascularcalcificationofchronickidneydisease |