Inhibitory effect of immune checkpoint cytotoxic t-lymphocyte- associated antigen-4 inhibitor combined with curcumin on tumor growth in mice with lung cancer
We aimed to investigate whether immune checkpoint cytotoxic T-lymphocyteassociated antigen-4 (CTLA-4) inhibitor plus curcumin can inhibit tumor growth in mice with lung cancer. A mouse model of lung cancer was established by injecting Lewis lung cancer cells. The mice were allocated to an anti-CTLA-...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Kafkas University, Faculty of Veterinary Medicine
2025-07-01
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| Series: | Kafkas Universitesi Veteriner Fakültesi Dergisi |
| Subjects: | |
| Online Access: | https://vetdergikafkas.org/pdf.php?id=3205 |
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| Summary: | We aimed to investigate whether immune checkpoint cytotoxic T-lymphocyteassociated
antigen-4 (CTLA-4) inhibitor plus curcumin can inhibit tumor growth in
mice with lung cancer. A mouse model of lung cancer was established by injecting
Lewis lung cancer cells. The mice were allocated to an anti-CTLA-4 group, a curcumin
group, an anti-CTLA-4+curcumin group, and a Model group in random (n=10). The
tumor inhibition rate and metastasis inhibition rate were calculated. Hematoxylin-eosin
staining was performed on tumor tissues for their pathological changes. The apoptosis
rate was measured by TUNEL assay. In comparison with the Model group, the tumor
volume, tumor mass, number of lung metastatic nodules, and the protein and relative
mRNA expressions of Bcl-2 in tumor tissues significantly decreased in anti-CTLA-4,
curcumin, and anti-CTLA-4+curcumin groups, while the tumor inhibition rate,
metastasis inhibition rate, apoptosis rate of tumor cells, and Caspase-3 and Bax contents
in tumor tissues increased (P<0.0001). CTLA-4 inhibitor plus curcumin can inhibit
tumor growth in mice with lung cancer, which may be associated with the promotion
of lung cancer cell apoptosis by regulating the Caspase-3/Bcl-2/Bax signaling pathway. |
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| ISSN: | 1309-2251 |