Immunomodulating activities of a natural α1 -acid glycoprotein and its carbohydrate chains attached to the Protein-Free Polymer
Immunomodulating effects of a neoglycoconjugate created on the basis of α1 -acid glycoprotein (AGP) carbohydrate chains and synthetic protein-free carrier have been investigated. It was demonstrated that this pseudo-AGP suppressed PHA- or anti-CD3 antibody-induced lymphocyte proliferation in a dosed...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
1998-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1080/09629359891270 |
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| author | A. L. Pukhalsky S. D. Shyian E. A. Kalashnikova G. V. Shmarina D. A. Pukhalskaya N. V. Bovin |
| author_facet | A. L. Pukhalsky S. D. Shyian E. A. Kalashnikova G. V. Shmarina D. A. Pukhalskaya N. V. Bovin |
| author_sort | A. L. Pukhalsky |
| collection | DOAJ |
| description | Immunomodulating effects of a neoglycoconjugate created on the basis of α1 -acid glycoprotein (AGP) carbohydrate chains and synthetic protein-free carrier have been investigated. It was demonstrated that this pseudo-AGP suppressed PHA- or anti-CD3 antibody-induced lymphocyte proliferation in a dosedependent manner. Pseudo-AGP revealed a similar antiproliferative effect as the natural AGP samples. Stimulation of the LPS-induced proinflammatory cytokine production by m ononuclear cells treated with both natural and pseudo-AGP has been also demonstrated. These data show that carbohydrate chains of AGP play a crucial role in the studied biological effect realization. |
| format | Article |
| id | doaj-art-6641af79e7e34d97ae82140245a82472 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 1998-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-6641af79e7e34d97ae82140245a824722025-02-03T01:33:12ZengWileyMediators of Inflammation0962-93511466-18611998-01-017211511810.1080/09629359891270Immunomodulating activities of a natural α1 -acid glycoprotein and its carbohydrate chains attached to the Protein-Free PolymerA. L. Pukhalsky0S. D. Shyian1E. A. Kalashnikova2G. V. Shmarina3D. A. Pukhalskaya4N. V. Bovin5Research Centre for Medical Genetics, 1 Moskvorechie Street, Moscow 115478, RussiaResearch Centre for Medical Genetics, 1 Moskvorechie Street, Moscow 115478, RussiaResearch Centre for Medical Genetics, 1 Moskvorechie Street, Moscow 115478, RussiaResearch Centre for Medical Genetics, 1 Moskvorechie Street, Moscow 115478, RussiaResearch Centre for Medical Genetics, 1 Moskvorechie Street, Moscow 115478, RussiaResearch Centre for Medical Genetics, 1 Moskvorechie Street, Moscow 115478, RussiaImmunomodulating effects of a neoglycoconjugate created on the basis of α1 -acid glycoprotein (AGP) carbohydrate chains and synthetic protein-free carrier have been investigated. It was demonstrated that this pseudo-AGP suppressed PHA- or anti-CD3 antibody-induced lymphocyte proliferation in a dosedependent manner. Pseudo-AGP revealed a similar antiproliferative effect as the natural AGP samples. Stimulation of the LPS-induced proinflammatory cytokine production by m ononuclear cells treated with both natural and pseudo-AGP has been also demonstrated. These data show that carbohydrate chains of AGP play a crucial role in the studied biological effect realization.http://dx.doi.org/10.1080/09629359891270 |
| spellingShingle | A. L. Pukhalsky S. D. Shyian E. A. Kalashnikova G. V. Shmarina D. A. Pukhalskaya N. V. Bovin Immunomodulating activities of a natural α1 -acid glycoprotein and its carbohydrate chains attached to the Protein-Free Polymer Mediators of Inflammation |
| title | Immunomodulating activities of a natural α1 -acid glycoprotein and its carbohydrate chains attached to the Protein-Free Polymer |
| title_full | Immunomodulating activities of a natural α1 -acid glycoprotein and its carbohydrate chains attached to the Protein-Free Polymer |
| title_fullStr | Immunomodulating activities of a natural α1 -acid glycoprotein and its carbohydrate chains attached to the Protein-Free Polymer |
| title_full_unstemmed | Immunomodulating activities of a natural α1 -acid glycoprotein and its carbohydrate chains attached to the Protein-Free Polymer |
| title_short | Immunomodulating activities of a natural α1 -acid glycoprotein and its carbohydrate chains attached to the Protein-Free Polymer |
| title_sort | immunomodulating activities of a natural α1 acid glycoprotein and its carbohydrate chains attached to the protein free polymer |
| url | http://dx.doi.org/10.1080/09629359891270 |
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