Short-Term Inhibition of NOX2 Prevents the Development of Aβ-Induced Pathology in Mice

Short-Term Inhibition of NOX2 Prevents the Development of Aβ-Induced Pathology in Mice

Alzheimer’s disease (AD) is the most common neurodegenerative disorder, characterized by the formation of neurotoxic beta-amyloid (Aβ) oligomers in the central nervous system. One of the earliest pathological effects of Aβ is the induction of oxidative stress in brain tissue, mediated by NADPH oxida...

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Bibliographic Details
Main Authors: Kristina A. Mukhina, Olga I. Kechko, Alexander A. Osypov, Irina Yu. Petrushanko, Alexander A. Makarov, Vladimir A. Mitkevich, Irina Yu. Popova
Format: Article
Language:English
Published: MDPI AG 2025-05-01
Series:Antioxidants
Subjects:
Alzheimer’s disease model
oligomeric Aβ
GSK2795039
neuroinflammation
oxidative stress
microglia
Online Access:https://www.mdpi.com/2076-3921/14/6/663
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