The Clinical Application of Gel-Based Composite Scaffolds in Rotator Cuff Repair
Rotator cuff tears are a common injury that can be treated with or without surgical intervention. Gel-based scaffolds have gained significant attention in the field of tissue engineering, particularly for applications like rotator cuff repair. Scaffolds can be biological, synthetic, or a mixture of...
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MDPI AG
2024-12-01
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| Online Access: | https://www.mdpi.com/2310-2861/11/1/2 |
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| author | Shebin Tharakan Michael Hadjiargyrou Azhar Ilyas |
| author_facet | Shebin Tharakan Michael Hadjiargyrou Azhar Ilyas |
| author_sort | Shebin Tharakan |
| collection | DOAJ |
| description | Rotator cuff tears are a common injury that can be treated with or without surgical intervention. Gel-based scaffolds have gained significant attention in the field of tissue engineering, particularly for applications like rotator cuff repair. Scaffolds can be biological, synthetic, or a mixture of both materials. Collagen, a primary constituent of the extracellular matrix (ECM) in musculoskeletal tissues, is one of the most widely used materials for gel-based scaffolds in rotator cuff repair, but other ECM-based and synthetic-based composite scaffolds have also been utilized. These composite scaffolds can be engineered to mimic the biomechanical and biological properties of natural tissues, supporting the healing process and promoting regeneration. Various clinical studies examined the effectiveness of these composite scaffolds with collagen, ECM and synthetic polymers and provided outstanding results with remarkable improvements in range of motion (ROM), strength, and pain. This review explores the material composition, manufacturing process and material properties of gel-based composite scaffolds as well as their clinical outcomes for the treatment of rotator cuff injuries. |
| format | Article |
| id | doaj-art-662fc3ebc6ef47d8a2561203e01c6dd8 |
| institution | Kabale University |
| issn | 2310-2861 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Gels |
| spelling | doaj-art-662fc3ebc6ef47d8a2561203e01c6dd82025-01-24T13:33:43ZengMDPI AGGels2310-28612024-12-01111210.3390/gels11010002The Clinical Application of Gel-Based Composite Scaffolds in Rotator Cuff RepairShebin Tharakan0Michael Hadjiargyrou1Azhar Ilyas2Bio-Nanotechnology and Biomaterials (BNB) Laboratory, New York Institute of Technology, Old Westbury, NY 11568, USADepartment of Biological & Chemical Sciences, New York Institute of Technology, Old Westbury, NY 11568, USABio-Nanotechnology and Biomaterials (BNB) Laboratory, New York Institute of Technology, Old Westbury, NY 11568, USARotator cuff tears are a common injury that can be treated with or without surgical intervention. Gel-based scaffolds have gained significant attention in the field of tissue engineering, particularly for applications like rotator cuff repair. Scaffolds can be biological, synthetic, or a mixture of both materials. Collagen, a primary constituent of the extracellular matrix (ECM) in musculoskeletal tissues, is one of the most widely used materials for gel-based scaffolds in rotator cuff repair, but other ECM-based and synthetic-based composite scaffolds have also been utilized. These composite scaffolds can be engineered to mimic the biomechanical and biological properties of natural tissues, supporting the healing process and promoting regeneration. Various clinical studies examined the effectiveness of these composite scaffolds with collagen, ECM and synthetic polymers and provided outstanding results with remarkable improvements in range of motion (ROM), strength, and pain. This review explores the material composition, manufacturing process and material properties of gel-based composite scaffolds as well as their clinical outcomes for the treatment of rotator cuff injuries.https://www.mdpi.com/2310-2861/11/1/2rotator cuffgel-based composite scaffoldsgraftsclinical outcomesaugmentationorthopedic surgery |
| spellingShingle | Shebin Tharakan Michael Hadjiargyrou Azhar Ilyas The Clinical Application of Gel-Based Composite Scaffolds in Rotator Cuff Repair Gels rotator cuff gel-based composite scaffolds grafts clinical outcomes augmentation orthopedic surgery |
| title | The Clinical Application of Gel-Based Composite Scaffolds in Rotator Cuff Repair |
| title_full | The Clinical Application of Gel-Based Composite Scaffolds in Rotator Cuff Repair |
| title_fullStr | The Clinical Application of Gel-Based Composite Scaffolds in Rotator Cuff Repair |
| title_full_unstemmed | The Clinical Application of Gel-Based Composite Scaffolds in Rotator Cuff Repair |
| title_short | The Clinical Application of Gel-Based Composite Scaffolds in Rotator Cuff Repair |
| title_sort | clinical application of gel based composite scaffolds in rotator cuff repair |
| topic | rotator cuff gel-based composite scaffolds grafts clinical outcomes augmentation orthopedic surgery |
| url | https://www.mdpi.com/2310-2861/11/1/2 |
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