Mammalian cells measure the extracellular matrix area and respond through switching the adhesion state

Abstract Mammalian cells adjust integrin-mediated adhesion based on the composition and structure of the extracellular matrix (ECM). However, how spatially confined ECM ligands regulate cell adhesion initiation remains unclear. Here, we investigate how cells adapt early adhesion to different ECM pro...

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Bibliographic Details
Main Authors: Xiaole Wang, Pengli Wang, Lihang Zhang, Tianyu Xu, Seungkuk Ahn, Upnishad Sharma, Han Yu, Nico Strohmeyer, Daniel J. Müller
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-62153-7
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