Atezolizumab-Induced Sarcoidosis-Like Reaction in a Patient with Metastatic Breast Cancer
Tumor-related sarcoidosis-like reactions (SLR) have been reported with the use of immune checkpoint inhibitors (ICIs). We report a case of 50-year-old woman who observed an enlarged lymph node in the right hilar region and the appearance of a subcutaneous mass in the extremities during chemotherapy...
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| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2022-01-01
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| Series: | Case Reports in Oncological Medicine |
| Online Access: | http://dx.doi.org/10.1155/2022/2709062 |
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| author | Akira Tsunoda Toshiro Mizuno Shohei Iida Katsunori Uchida Masako Yamashita Koshi Sukeno Hiroki Oka Yasutaka Tono Mikiya Ishihara Kanako Saito Satoshi Tamaru Keiichi Yamanaka Isao Tawara |
| author_facet | Akira Tsunoda Toshiro Mizuno Shohei Iida Katsunori Uchida Masako Yamashita Koshi Sukeno Hiroki Oka Yasutaka Tono Mikiya Ishihara Kanako Saito Satoshi Tamaru Keiichi Yamanaka Isao Tawara |
| author_sort | Akira Tsunoda |
| collection | DOAJ |
| description | Tumor-related sarcoidosis-like reactions (SLR) have been reported with the use of immune checkpoint inhibitors (ICIs). We report a case of 50-year-old woman who observed an enlarged lymph node in the right hilar region and the appearance of a subcutaneous mass in the extremities during chemotherapy with atezolizumab plus nab-paclitaxel for metastatic triple-negative breast cancer (TNBC). Skin biopsy revealed the formation of epithelioid granulation species with the Langhans giant cell. After discontinuing atezolizumab in the treatment procedure, the hilar lymph nodes and the subcutaneous mass were reduced. A pathological examination was effective in differentiating tumor exacerbation from SLR. Owing to limited information on ICI-related SLR in breast cancer, future studies are recommended to properly manage immune-related adverse effects during cancer treatment. |
| format | Article |
| id | doaj-art-662c3e25bcab458d9add23d897ead289 |
| institution | Kabale University |
| issn | 2090-6714 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Oncological Medicine |
| spelling | doaj-art-662c3e25bcab458d9add23d897ead2892025-02-03T00:59:06ZengWileyCase Reports in Oncological Medicine2090-67142022-01-01202210.1155/2022/2709062Atezolizumab-Induced Sarcoidosis-Like Reaction in a Patient with Metastatic Breast CancerAkira Tsunoda0Toshiro Mizuno1Shohei Iida2Katsunori Uchida3Masako Yamashita4Koshi Sukeno5Hiroki Oka6Yasutaka Tono7Mikiya Ishihara8Kanako Saito9Satoshi Tamaru10Keiichi Yamanaka11Isao Tawara12Department of Medical OncologyDepartment of Medical OncologyDepartment of DermatologyDepartment of Oncologic PathologyDepartment of Breast SurgeryDepartment of Medical OncologyDepartment of Medical OncologyDepartment of Medical OncologyDepartment of Medical OncologyDepartment of Medical OncologyDepartment of Medical OncologyDepartment of DermatologyDepartment of Medical OncologyTumor-related sarcoidosis-like reactions (SLR) have been reported with the use of immune checkpoint inhibitors (ICIs). We report a case of 50-year-old woman who observed an enlarged lymph node in the right hilar region and the appearance of a subcutaneous mass in the extremities during chemotherapy with atezolizumab plus nab-paclitaxel for metastatic triple-negative breast cancer (TNBC). Skin biopsy revealed the formation of epithelioid granulation species with the Langhans giant cell. After discontinuing atezolizumab in the treatment procedure, the hilar lymph nodes and the subcutaneous mass were reduced. A pathological examination was effective in differentiating tumor exacerbation from SLR. Owing to limited information on ICI-related SLR in breast cancer, future studies are recommended to properly manage immune-related adverse effects during cancer treatment.http://dx.doi.org/10.1155/2022/2709062 |
| spellingShingle | Akira Tsunoda Toshiro Mizuno Shohei Iida Katsunori Uchida Masako Yamashita Koshi Sukeno Hiroki Oka Yasutaka Tono Mikiya Ishihara Kanako Saito Satoshi Tamaru Keiichi Yamanaka Isao Tawara Atezolizumab-Induced Sarcoidosis-Like Reaction in a Patient with Metastatic Breast Cancer Case Reports in Oncological Medicine |
| title | Atezolizumab-Induced Sarcoidosis-Like Reaction in a Patient with Metastatic Breast Cancer |
| title_full | Atezolizumab-Induced Sarcoidosis-Like Reaction in a Patient with Metastatic Breast Cancer |
| title_fullStr | Atezolizumab-Induced Sarcoidosis-Like Reaction in a Patient with Metastatic Breast Cancer |
| title_full_unstemmed | Atezolizumab-Induced Sarcoidosis-Like Reaction in a Patient with Metastatic Breast Cancer |
| title_short | Atezolizumab-Induced Sarcoidosis-Like Reaction in a Patient with Metastatic Breast Cancer |
| title_sort | atezolizumab induced sarcoidosis like reaction in a patient with metastatic breast cancer |
| url | http://dx.doi.org/10.1155/2022/2709062 |
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