Predicting residual pain after vertebral augmentation in vertebral compression fractures: a systematic review and critical appraisal of risk prediction models

Abstract Background Patients with vertebral compression fractures may experience unpredictable residual pain following vertebral augmentation. Clinical prediction models have shown potential for early prevention and intervention of such residual pain. However, studies focusing on the quality and acc...

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Main Authors: Siyi Wang, Mingpeng Shi, Xue Zhou, Jianan Yu, Mingze Han, Xianshuai Zhang, Zhenhua Li, Xinhua Chen
Format: Article
Language:English
Published: BMC 2025-01-01
Series:BMC Musculoskeletal Disorders
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Online Access:https://doi.org/10.1186/s12891-025-08338-z
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author Siyi Wang
Mingpeng Shi
Xue Zhou
Jianan Yu
Mingze Han
Xianshuai Zhang
Zhenhua Li
Xinhua Chen
author_facet Siyi Wang
Mingpeng Shi
Xue Zhou
Jianan Yu
Mingze Han
Xianshuai Zhang
Zhenhua Li
Xinhua Chen
author_sort Siyi Wang
collection DOAJ
description Abstract Background Patients with vertebral compression fractures may experience unpredictable residual pain following vertebral augmentation. Clinical prediction models have shown potential for early prevention and intervention of such residual pain. However, studies focusing on the quality and accuracy of these prediction models are lacking. Therefore, we systematically reviewed and critically evaluated prediction models for residual pain following vertebral augmentation. Methods We systematically searched eight databases (PubMed, Embase, Web of Science, CNKI, WanFang, VIP, and SinoMed) for studies that developed and/or validated risk prediction models for residual pain after vertebral augmentation. The limitations of existing models were critically assessed using the PROBAST tool. We performed a descriptive analysis of the models' characteristics and predictors. Extracted C-statistics were combined using a weighted approach based on the Restricted Maximum Likelihood (REML) method to represent the models' average performance. All statistical analyses were performed using R 4.3.1 and STATA 17 software. Results Fifteen models were evaluated, involving 4802 patients with vertebral compression fractures post-vertebral augmentation. The overall pooled C-statistic was 0.87, with a 95% CI of 0.83 to 0.89 and a prediction interval ranging from 0.72 to 0.94. The models included 35 different predictors, with posterior fascia injury (PFI), bone mineral density (BMD), and intravertebral vacuum cleft (IVC) being the most common. Most models were rated high risk due to concerns about population selection and modeling methodology, yet their clinical applicability remains promising. Conclusion The development and validation of current models exhibit a certain risk of bias, and our study highlights these existing flaws and limitations. Although these models demonstrate satisfactory predictive performance and clinical applicability, further external validation is needed to confirm their accuracy in clinical practice. Clinicians can utilize these models alongside relevant risk factors to predict and prevent residual pain after vertebral augmentation, or to formulate personalized treatment plans.
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spelling doaj-art-66296a4736554e47ba138b0ebde6e1532025-02-02T12:05:24ZengBMCBMC Musculoskeletal Disorders1471-24742025-01-0126112010.1186/s12891-025-08338-zPredicting residual pain after vertebral augmentation in vertebral compression fractures: a systematic review and critical appraisal of risk prediction modelsSiyi Wang0Mingpeng Shi1Xue Zhou2Jianan Yu3Mingze Han4Xianshuai Zhang5Zhenhua Li6Xinhua Chen7College of Acupuncture and Massage, Changchun University of Chinese MedicineCollege of Traditional Chinese Medicine, Changchun University of Chinese MedicineCollege of Acupuncture and Massage, Changchun University of Chinese MedicineCollege of Traditional Chinese Medicine, Changchun University of Chinese MedicineCollege of Traditional Chinese Medicine, Changchun University of Chinese MedicineDepartment of Orthopedics, Affiliated Hospital of Changchun University of Chinese MedicineDepartment of Orthopedics, Affiliated Hospital of Changchun University of Chinese MedicineDepartment of Acupuncture and Moxibustion, Affiliated Hospital of Changchun University of Chinese MedicineAbstract Background Patients with vertebral compression fractures may experience unpredictable residual pain following vertebral augmentation. Clinical prediction models have shown potential for early prevention and intervention of such residual pain. However, studies focusing on the quality and accuracy of these prediction models are lacking. Therefore, we systematically reviewed and critically evaluated prediction models for residual pain following vertebral augmentation. Methods We systematically searched eight databases (PubMed, Embase, Web of Science, CNKI, WanFang, VIP, and SinoMed) for studies that developed and/or validated risk prediction models for residual pain after vertebral augmentation. The limitations of existing models were critically assessed using the PROBAST tool. We performed a descriptive analysis of the models' characteristics and predictors. Extracted C-statistics were combined using a weighted approach based on the Restricted Maximum Likelihood (REML) method to represent the models' average performance. All statistical analyses were performed using R 4.3.1 and STATA 17 software. Results Fifteen models were evaluated, involving 4802 patients with vertebral compression fractures post-vertebral augmentation. The overall pooled C-statistic was 0.87, with a 95% CI of 0.83 to 0.89 and a prediction interval ranging from 0.72 to 0.94. The models included 35 different predictors, with posterior fascia injury (PFI), bone mineral density (BMD), and intravertebral vacuum cleft (IVC) being the most common. Most models were rated high risk due to concerns about population selection and modeling methodology, yet their clinical applicability remains promising. Conclusion The development and validation of current models exhibit a certain risk of bias, and our study highlights these existing flaws and limitations. Although these models demonstrate satisfactory predictive performance and clinical applicability, further external validation is needed to confirm their accuracy in clinical practice. Clinicians can utilize these models alongside relevant risk factors to predict and prevent residual pain after vertebral augmentation, or to formulate personalized treatment plans.https://doi.org/10.1186/s12891-025-08338-zResidual painPrediction modelVertebral augmentationVertebral compression fracturesSystematic review
spellingShingle Siyi Wang
Mingpeng Shi
Xue Zhou
Jianan Yu
Mingze Han
Xianshuai Zhang
Zhenhua Li
Xinhua Chen
Predicting residual pain after vertebral augmentation in vertebral compression fractures: a systematic review and critical appraisal of risk prediction models
BMC Musculoskeletal Disorders
Residual pain
Prediction model
Vertebral augmentation
Vertebral compression fractures
Systematic review
title Predicting residual pain after vertebral augmentation in vertebral compression fractures: a systematic review and critical appraisal of risk prediction models
title_full Predicting residual pain after vertebral augmentation in vertebral compression fractures: a systematic review and critical appraisal of risk prediction models
title_fullStr Predicting residual pain after vertebral augmentation in vertebral compression fractures: a systematic review and critical appraisal of risk prediction models
title_full_unstemmed Predicting residual pain after vertebral augmentation in vertebral compression fractures: a systematic review and critical appraisal of risk prediction models
title_short Predicting residual pain after vertebral augmentation in vertebral compression fractures: a systematic review and critical appraisal of risk prediction models
title_sort predicting residual pain after vertebral augmentation in vertebral compression fractures a systematic review and critical appraisal of risk prediction models
topic Residual pain
Prediction model
Vertebral augmentation
Vertebral compression fractures
Systematic review
url https://doi.org/10.1186/s12891-025-08338-z
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