Mannose-B from Codonopsis pilosula modulates LAMB1 expression to enhance trophoblast function and alleviate subchorionic hematoma

Mannose-B from Codonopsis pilosula modulates LAMB1 expression to enhance trophoblast function and alleviate subchorionic hematoma

Abstract This study investigates the active component Mannose-B from Codonopsis pilosula and its effect on human trophoblast cell function, particularly focusing on the regulation of Laminin Subunit Beta 1 (LAMB1) expression and its implications in subchorionic hematoma (SCH). Key genes involved in...

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Bibliographic Details
Main Authors: Qian Sun, Yuan Gao, Kadirya Asan, Jing Ji, Jinjin Xu, Xiaoyan Wu, Jie Ren, Wen Feng, Mengwei Song, Sen Wang, Boyu Zhang, Ying Zhou, Conghui Han, Shun Liu, Wen Yang
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Scientific Reports
Subjects:
Subchorionic hematoma
Codonopsis pilosula
Mannose-B
Laminin subunit beta 1
Trophoblast cells
Network pharmacology
Online Access:https://doi.org/10.1038/s41598-025-13918-z
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