Multidimensional investigation of thyroid hormones and prostate cancer: insights from NHANES, Mendelian randomization, genetic markers, and bioinformatics analyses

Multidimensional investigation of thyroid hormones and prostate cancer: insights from NHANES, Mendelian randomization, genetic markers, and bioinformatics analyses

Abstract Background Prostate cancer remains a major global health burden for men, with its incidence and mortality steadily rising. Thyroid hormones, critical regulators of metabolism and cell growth, have been implicated in tumorigenesis, yet their specific role in prostate cancer risk remains uncl...

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Bibliographic Details
Main Authors: Jinhai Wu, Sian Chen, Ran Xu, Yanfei Chen, Jiadin Guo, Jing Li, Xiheng Zeng, Bin Wang, Xuejin Zhu
Format: Article
Language:English
Published: Springer 2025-05-01
Series:Discover Oncology
Subjects:
Thyroid hormones
Prostate cancer
NHANES
Mendelian randomization
ADM5
INPP5B
Online Access:https://doi.org/10.1007/s12672-025-02672-3
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