Design, Synthesis, and Biological Evaluation of 5,8-Dimethyl Shikonin Oximes as SARS-CoV-2 M<sup>pro</sup> Inhibitors

Design, Synthesis, and Biological Evaluation of 5,8-Dimethyl Shikonin Oximes as SARS-CoV-2 M<sup>pro</sup> Inhibitors

We have designed, synthesized, and characterized a small library of shikonin derivatives and demonstrated their inhibitory activity against the main protease, M<sup>pro</sup>, of SARS-CoV-2. One analog, 5,8-dimethyl shikonin oxime (<b>15</b>), exhibited the highest activity a...

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Bibliographic Details
Main Authors: Jiahua Cui, Shouyan Xiang, Qijing Zhang, Shangqing Xiao, Gaoyang Yuan, Chenwu Liu, Shaoshun Li
Format: Article
Language:English
Published: MDPI AG 2025-03-01
Series:Molecules
Subjects:
SARS-CoV-2 M<sup>pro</sup>
shikonin
dimethyl shikonin oximes
inhibitors
COVID-19
Online Access:https://www.mdpi.com/1420-3049/30/6/1321
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