THE POSSIBILITY OF TREATING PATIENTS WITH GASTRIC CANCER WITH METASTASES TO THE BONES OF THE SKELETON
The results of treatment of 14 patients with gastric cancer with metastases to the bones of the skeleton were analized, which was conducted by the stabilization of metastatic spine vertebroplasty, systemic radionuclide therapy with samarium-153 oksabifor and intravenous infusion by Zolendronic ...
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| Language: | English |
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Bashkir State Medical University
2017-02-01
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| Series: | Креативная хирургия и онкология |
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| Online Access: | https://www.surgonco.ru/jour/article/view/173 |
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| author | N. V. Rasulova D. T. Arybzhanov F. Z. Dzhalalov Kyeong Hwan Kim |
| author_facet | N. V. Rasulova D. T. Arybzhanov F. Z. Dzhalalov Kyeong Hwan Kim |
| author_sort | N. V. Rasulova |
| collection | DOAJ |
| description | The results of treatment of 14 patients with gastric cancer with metastases to the bones of the skeleton were analized, which was conducted by the stabilization of metastatic spine vertebroplasty, systemic radionuclide therapy with samarium-153 oksabifor and intravenous infusion by Zolendronic acid 4 mg 1 time in 28 days. When applying this method decreased by stabilizing vertebral pain occurred in the first 12 hours after vertebroplasty (cf. value 4.8±1,2 hours, from 30 minutes to 12 hours), the average pain intensity decreased to 4.5 ±0,6 (from 2 to 6). After the treatment of bone metastases with samarium-153 oksa bifor, pain intensity decreased by 3,9 ± 0,3 days (range from 2 to 6) and reached the level of 0,9 ± 0,5 (from 0 to 2). Value pain scores before and after treatment was significantly different, and was P <0,0001. Thus, the combination of vertebroplasty, radionuclide therapy with samarium-153 oksabifor and systemic therapy with bisphosphonates (Zolendronic acid) in patients with gastric cancer with bone metastases can be treated in the presence or threat of vertebral fractures, which gives an opportunity to expand the indications for palliative radionuclide therapy and improve efficiency treatment of severe category of patients with multiple bone metastases and pain. The proposed approach allows us to quickly achieve durable and pronounced reduction in pain intensity, significantly reduce the need for analgesics. |
| format | Article |
| id | doaj-art-66191bc2d8034f39832d208e2e88925c |
| institution | Kabale University |
| issn | 2076-3093 2307-0501 |
| language | English |
| publishDate | 2017-02-01 |
| publisher | Bashkir State Medical University |
| record_format | Article |
| series | Креативная хирургия и онкология |
| spelling | doaj-art-66191bc2d8034f39832d208e2e88925c2025-08-20T03:57:35ZengBashkir State Medical UniversityКреативная хирургия и онкология2076-30932307-05012017-02-0103525710.24060/2076-3093-2013-0-3-52-57173THE POSSIBILITY OF TREATING PATIENTS WITH GASTRIC CANCER WITH METASTASES TO THE BONES OF THE SKELETONN. V. Rasulova0D. T. Arybzhanov1F. Z. Dzhalalov2Kyeong Hwan Kim3Acad. V. Vakhidov’s Republican Specialized Center of SurgerySouth Kazakhstan Regional Oncology CenterNational Research Centre for Emergency MedicineHospital HyundaiThe results of treatment of 14 patients with gastric cancer with metastases to the bones of the skeleton were analized, which was conducted by the stabilization of metastatic spine vertebroplasty, systemic radionuclide therapy with samarium-153 oksabifor and intravenous infusion by Zolendronic acid 4 mg 1 time in 28 days. When applying this method decreased by stabilizing vertebral pain occurred in the first 12 hours after vertebroplasty (cf. value 4.8±1,2 hours, from 30 minutes to 12 hours), the average pain intensity decreased to 4.5 ±0,6 (from 2 to 6). After the treatment of bone metastases with samarium-153 oksa bifor, pain intensity decreased by 3,9 ± 0,3 days (range from 2 to 6) and reached the level of 0,9 ± 0,5 (from 0 to 2). Value pain scores before and after treatment was significantly different, and was P <0,0001. Thus, the combination of vertebroplasty, radionuclide therapy with samarium-153 oksabifor and systemic therapy with bisphosphonates (Zolendronic acid) in patients with gastric cancer with bone metastases can be treated in the presence or threat of vertebral fractures, which gives an opportunity to expand the indications for palliative radionuclide therapy and improve efficiency treatment of severe category of patients with multiple bone metastases and pain. The proposed approach allows us to quickly achieve durable and pronounced reduction in pain intensity, significantly reduce the need for analgesics.https://www.surgonco.ru/jour/article/view/173systemic radionuclide therapyvertebroplastybone metastasesspinal fracture |
| spellingShingle | N. V. Rasulova D. T. Arybzhanov F. Z. Dzhalalov Kyeong Hwan Kim THE POSSIBILITY OF TREATING PATIENTS WITH GASTRIC CANCER WITH METASTASES TO THE BONES OF THE SKELETON Креативная хирургия и онкология systemic radionuclide therapy vertebroplasty bone metastases spinal fracture |
| title | THE POSSIBILITY OF TREATING PATIENTS WITH GASTRIC CANCER WITH METASTASES TO THE BONES OF THE SKELETON |
| title_full | THE POSSIBILITY OF TREATING PATIENTS WITH GASTRIC CANCER WITH METASTASES TO THE BONES OF THE SKELETON |
| title_fullStr | THE POSSIBILITY OF TREATING PATIENTS WITH GASTRIC CANCER WITH METASTASES TO THE BONES OF THE SKELETON |
| title_full_unstemmed | THE POSSIBILITY OF TREATING PATIENTS WITH GASTRIC CANCER WITH METASTASES TO THE BONES OF THE SKELETON |
| title_short | THE POSSIBILITY OF TREATING PATIENTS WITH GASTRIC CANCER WITH METASTASES TO THE BONES OF THE SKELETON |
| title_sort | possibility of treating patients with gastric cancer with metastases to the bones of the skeleton |
| topic | systemic radionuclide therapy vertebroplasty bone metastases spinal fracture |
| url | https://www.surgonco.ru/jour/article/view/173 |
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