Development of eugenol derivatives with 5-LOX inhibitory activity

Development of eugenol derivatives with 5-LOX inhibitory activity

Eugenol (4-allyl-2-methoxyphenol), is the major chemical constituent in the essential oil of numerous plant species. Several biological properties have been described for this molecule, including modulation of enzymatic targets relevant for the inflammatory response, such as 5-lipoxygenase (5-LOX)....

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Main Authors: José L. Pereira Filho, Renato B. Pereira, Tatiana F. Vieira, Sérgio F. Sousa, José R. A. Coelho, Nuno F. S. Pinto, Catarina M. M. Coelho, Maria José G. Fernandes, Elisabete M. S. Castanheira, Maria S. T. Gonçalves, David M. Pereira
Format: Article
Language:English
Published: Taylor & Francis Group 2025-12-01
Series:Journal of Enzyme Inhibition and Medicinal Chemistry
Subjects:
Eugenol
5-lipoxygenase
in silico
chemometrics
Online Access:https://www.tandfonline.com/doi/10.1080/14756366.2025.2535586
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