GIMAP8 could serve as a potential prognostic factor for lung adenocarcinoma and is closely related to immunity
Abstract GTPase IMAP family member 8 (GIMAP8) plays a key role in pathophysiology of several malignancies. The objective of this current research endeavor was to investigate the prognosis value of GIMAP8 in lung adenocarcinoma and examine how it relates to immunity. Expression profiles associated wi...
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Nature Portfolio
2025-05-01
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| Series: | Scientific Reports |
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| Online Access: | https://doi.org/10.1038/s41598-025-99894-w |
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| author | Xinfeng Wei Wei Wei Hongmei Liu Junxuan Yi Mingwei Wang Weiqiang Xu Mingqi Zhao Mengdie Zhao Rong Wang Shunzi Jin |
| author_facet | Xinfeng Wei Wei Wei Hongmei Liu Junxuan Yi Mingwei Wang Weiqiang Xu Mingqi Zhao Mengdie Zhao Rong Wang Shunzi Jin |
| author_sort | Xinfeng Wei |
| collection | DOAJ |
| description | Abstract GTPase IMAP family member 8 (GIMAP8) plays a key role in pathophysiology of several malignancies. The objective of this current research endeavor was to investigate the prognosis value of GIMAP8 in lung adenocarcinoma and examine how it relates to immunity. Expression profiles associated with GIMAP8 and related clinical details were acquired from The Cancer Genome Atlas database, and we conducted survival analysis, enrichment analysis and immune infiltration studies. Additionally, we evaluated the effect of GIMAP8 on radiation resistance of tumor by in vivo and in vitro experiments. Our results showed that lung adenocarcinoma tumor tissues exhibited lower GIMAP8 levels compared to nearby normal tissues. Furthermore, decreased GIMAP8 expression strongly correlated with poorer OS. The expression of GIMAP8 is closely related to the formation of radiation resistance in tumor cells. GSEA identified multiple signaling pathways linked to GIMAP8, including immune-related, chemokine, cell adhesion molecule, and NF-κB signaling pathways. GIMAP8 expression strongly correlated with the expression of immune checkpoint molecules, tumor mutational burden, tumor neoantigen burden, immune cells, and tumor immune microenvironment. GIMAP8 was found to have an inhibitory effect on lung adenocarcinoma and was closely related to the immune response. Moreover, GIMAP8 may also influence radiation resistance in tumors. |
| format | Article |
| id | doaj-art-6612f44e30ae4e63b0b9d5d933106856 |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-6612f44e30ae4e63b0b9d5d9331068562025-08-20T03:52:20ZengNature PortfolioScientific Reports2045-23222025-05-0115111410.1038/s41598-025-99894-wGIMAP8 could serve as a potential prognostic factor for lung adenocarcinoma and is closely related to immunityXinfeng Wei0Wei Wei1Hongmei Liu2Junxuan Yi3Mingwei Wang4Weiqiang Xu5Mingqi Zhao6Mengdie Zhao7Rong Wang8Shunzi Jin9NHC Key Laboratory of Radiobiology, School of Public Health, Jilin UniversityDepartment of Radiation Oncology, Senior Department of Oncology, The Fifth Medical Center of PLA General HospitalNanguan Hospital of Bethune Second Hospital of Jilin UniversityNHC Key Laboratory of Radiobiology, School of Public Health, Jilin UniversityNHC Key Laboratory of Radiobiology, School of Public Health, Jilin UniversityNHC Key Laboratory of Radiobiology, School of Public Health, Jilin UniversityNHC Key Laboratory of Radiobiology, School of Public Health, Jilin UniversityNHC Key Laboratory of Radiobiology, School of Public Health, Jilin UniversityDepartment of Radiation Oncology, Zhongshan City People’s HospitalNHC Key Laboratory of Radiobiology, School of Public Health, Jilin UniversityAbstract GTPase IMAP family member 8 (GIMAP8) plays a key role in pathophysiology of several malignancies. The objective of this current research endeavor was to investigate the prognosis value of GIMAP8 in lung adenocarcinoma and examine how it relates to immunity. Expression profiles associated with GIMAP8 and related clinical details were acquired from The Cancer Genome Atlas database, and we conducted survival analysis, enrichment analysis and immune infiltration studies. Additionally, we evaluated the effect of GIMAP8 on radiation resistance of tumor by in vivo and in vitro experiments. Our results showed that lung adenocarcinoma tumor tissues exhibited lower GIMAP8 levels compared to nearby normal tissues. Furthermore, decreased GIMAP8 expression strongly correlated with poorer OS. The expression of GIMAP8 is closely related to the formation of radiation resistance in tumor cells. GSEA identified multiple signaling pathways linked to GIMAP8, including immune-related, chemokine, cell adhesion molecule, and NF-κB signaling pathways. GIMAP8 expression strongly correlated with the expression of immune checkpoint molecules, tumor mutational burden, tumor neoantigen burden, immune cells, and tumor immune microenvironment. GIMAP8 was found to have an inhibitory effect on lung adenocarcinoma and was closely related to the immune response. Moreover, GIMAP8 may also influence radiation resistance in tumors.https://doi.org/10.1038/s41598-025-99894-wGIMAP8Lung adenocarcinomaPrognosisImmunityTCGA |
| spellingShingle | Xinfeng Wei Wei Wei Hongmei Liu Junxuan Yi Mingwei Wang Weiqiang Xu Mingqi Zhao Mengdie Zhao Rong Wang Shunzi Jin GIMAP8 could serve as a potential prognostic factor for lung adenocarcinoma and is closely related to immunity Scientific Reports GIMAP8 Lung adenocarcinoma Prognosis Immunity TCGA |
| title | GIMAP8 could serve as a potential prognostic factor for lung adenocarcinoma and is closely related to immunity |
| title_full | GIMAP8 could serve as a potential prognostic factor for lung adenocarcinoma and is closely related to immunity |
| title_fullStr | GIMAP8 could serve as a potential prognostic factor for lung adenocarcinoma and is closely related to immunity |
| title_full_unstemmed | GIMAP8 could serve as a potential prognostic factor for lung adenocarcinoma and is closely related to immunity |
| title_short | GIMAP8 could serve as a potential prognostic factor for lung adenocarcinoma and is closely related to immunity |
| title_sort | gimap8 could serve as a potential prognostic factor for lung adenocarcinoma and is closely related to immunity |
| topic | GIMAP8 Lung adenocarcinoma Prognosis Immunity TCGA |
| url | https://doi.org/10.1038/s41598-025-99894-w |
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