Estradiol Reverses Ovariectomy-Induced Disruption of Hypothalamic Gene Expression and Behavior via Modulation of Gonadotropin Releasing Hormone and Calcium Signaling Pathways

Estradiol Reverses Ovariectomy-Induced Disruption of Hypothalamic Gene Expression and Behavior via Modulation of Gonadotropin Releasing Hormone and Calcium Signaling Pathways

Estrogen plays a crucial role in regulating reproductive and neuroendocrine functions, yet the molecular mechanisms underlying its effects on the hypothalamus remain incompletely understood. This study investigates the transcriptional and behavioral changes induced by ovariectomy (OVX) and estradiol...

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Main Authors: Asim Muhammad, Mubashir Muhammad, Xiaohuan Chao, Chunlei Zhang, Jiahao Chen, Huan Yang, Shuhan Liu, Yuan Ding, Ziming Wang, Hongwei Bi, Wen Guo, Junhong Fan, Bo Zhou
Format: Article
Language:English
Published: MDPI AG 2025-05-01
Series:Animals
Subjects:
ovariectomy
estradiol intervention
hypothalamic transcriptomics
GnRH signaling pathway
calcium signaling pathway
reproductive aging
Online Access:https://www.mdpi.com/2076-2615/15/10/1467
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