Modification of the telomerase gene with human regulatory sequences resets mouse telomeres to human length
Abstract Telomeres shorten with each cell division, serving as biomarkers of aging, with human tissues exhibiting short telomeres and restricted telomerase expression. In contrast, mice have longer telomeres and widespread telomerase activity, limiting their relevance as models for human telomere bi...
Saved in:
Main Authors: | Fan Zhang, De Cheng, Kenneth I. Porter, Emily A. Heck, Shuwen Wang, Hui Zhang, Christopher J. Davis, Gavin P. Robertson, Jiyue Zhu |
---|---|
Format: | Article |
Language: | English |
Published: |
Nature Portfolio
2025-02-01
|
Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/s41467-025-56559-6 |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Similar Items
-
Telomeres, telomerase, and cancer: mechanisms, biomarkers, and therapeutics
by: Songting Shou, et al.
Published: (2025-01-01) -
Compilation and functional classification of telomere length-associated genes in humans and other animal species
by: E. V. Ignatieva, et al.
Published: (2023-06-01) -
Usefulness of Immunological Detection of the Human Telomerase Reverse Transcriptase
by: Annalisa Volpi, et al.
Published: (2005-01-01) -
Telomere length as a quantitative trait: genome-wide survey and genetic mapping of telomere length-control genes in yeast.
by: Tonibelle Gatbonton, et al.
Published: (2006-03-01) -
The multi-omics signatures of telomere length in childhood
by: Congrong Wang, et al.
Published: (2025-01-01)