Nano‐Octahedron Cobalt Oxide Decorated Graphene Nanocomposites for the Selective/Simultaneous Detection of Dopamine
Abstract Nano‐octahedron cobalt oxide decorated graphene nanocomposite is reported in this work for selective and simultaneous determination of dopamine (DA) and uric acid (UA). The composite is synthesized using a hydrothermal method and characterized to identify the crystal structure and its shape...
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| Language: | English |
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Wiley-VCH
2025-07-01
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| Series: | Advanced Materials Interfaces |
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| Online Access: | https://doi.org/10.1002/admi.202400981 |
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| author | Swathi Tharani Dharmalingam Mushtaq Ahmad Dar Rukhsana Gul Manickam Minakshi Sundaram Ibrahim Abdullah Alnaser R. Sivasubramanian |
| author_facet | Swathi Tharani Dharmalingam Mushtaq Ahmad Dar Rukhsana Gul Manickam Minakshi Sundaram Ibrahim Abdullah Alnaser R. Sivasubramanian |
| author_sort | Swathi Tharani Dharmalingam |
| collection | DOAJ |
| description | Abstract Nano‐octahedron cobalt oxide decorated graphene nanocomposite is reported in this work for selective and simultaneous determination of dopamine (DA) and uric acid (UA). The composite is synthesized using a hydrothermal method and characterized to identify the crystal structure and its shapes. The Scanning Electron Microscope (SEM) and Transmission Electron Microscope (TEM) images indicate the silhouette image of the nanocube decorated over graphene oxide. The Gr‐Co₃O₄/glassy carbon electrode (GCE) is utilized for the electrochemical detection of dopamine (DA). Cyclic voltammetry (CV) studies revealed a significant breakthrough such as Gr‐Co₃O₄/GCE exhibited higher electrocatalytic activity for DA oxidation than the bare GCE. Differential pulse voltammetry (DPV) measurements demonstrated a detection limit of 0.09 µM for DA, with a linear response range from 1 to 500 µM. For uric acid (UA), the detection limit and linear range are estimated as 0.2 and 100 to 8000 µM, respectively. The sensor selectively detects DA in the presence of UA is confirmed, with a peak separation of 250 mV between DA and UA. The reliability of the sensor is validated through using human serum specimens, paving the way for exciting potential applications in biomedical research and clinical diagnostics. |
| format | Article |
| id | doaj-art-660a28d56f4d4d42907ef34de2b96deb |
| institution | DOAJ |
| issn | 2196-7350 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Wiley-VCH |
| record_format | Article |
| series | Advanced Materials Interfaces |
| spelling | doaj-art-660a28d56f4d4d42907ef34de2b96deb2025-08-20T02:40:59ZengWiley-VCHAdvanced Materials Interfaces2196-73502025-07-011213n/an/a10.1002/admi.202400981Nano‐Octahedron Cobalt Oxide Decorated Graphene Nanocomposites for the Selective/Simultaneous Detection of DopamineSwathi Tharani Dharmalingam0Mushtaq Ahmad Dar1Rukhsana Gul2Manickam Minakshi Sundaram3Ibrahim Abdullah Alnaser4R. Sivasubramanian5Electrochemical Sensor and Energy Materials Laboratory PSG Institute of Advanced Studies Coimbatore Tamil Nadu 641004 IndiaCenter of Excellence for Research in Engineering Materials Deanship of Scientific Research (DSR), King Saud University Riyadh 11421 Kingdom of Saudi ArabiaObesity Research Center King Saud University Riyadh 11461 Kingdom of Saudi ArabiaCollege of Science, Health, Engineering and Education Murdoch University Perth WA 6150 AustraliaMechanical Engineering Department College of Engineering King Saud University Riyadh 11421 Kingdom of Saudi ArabiaDepartment of Chemistry School of Engineering, Amrita Vishwa Vidyapeetham Amaravati Andhra Pradesh 522503 IndiaAbstract Nano‐octahedron cobalt oxide decorated graphene nanocomposite is reported in this work for selective and simultaneous determination of dopamine (DA) and uric acid (UA). The composite is synthesized using a hydrothermal method and characterized to identify the crystal structure and its shapes. The Scanning Electron Microscope (SEM) and Transmission Electron Microscope (TEM) images indicate the silhouette image of the nanocube decorated over graphene oxide. The Gr‐Co₃O₄/glassy carbon electrode (GCE) is utilized for the electrochemical detection of dopamine (DA). Cyclic voltammetry (CV) studies revealed a significant breakthrough such as Gr‐Co₃O₄/GCE exhibited higher electrocatalytic activity for DA oxidation than the bare GCE. Differential pulse voltammetry (DPV) measurements demonstrated a detection limit of 0.09 µM for DA, with a linear response range from 1 to 500 µM. For uric acid (UA), the detection limit and linear range are estimated as 0.2 and 100 to 8000 µM, respectively. The sensor selectively detects DA in the presence of UA is confirmed, with a peak separation of 250 mV between DA and UA. The reliability of the sensor is validated through using human serum specimens, paving the way for exciting potential applications in biomedical research and clinical diagnostics.https://doi.org/10.1002/admi.202400981Co3O4dopamineDPVgrapheneuric acid |
| spellingShingle | Swathi Tharani Dharmalingam Mushtaq Ahmad Dar Rukhsana Gul Manickam Minakshi Sundaram Ibrahim Abdullah Alnaser R. Sivasubramanian Nano‐Octahedron Cobalt Oxide Decorated Graphene Nanocomposites for the Selective/Simultaneous Detection of Dopamine Advanced Materials Interfaces Co3O4 dopamine DPV graphene uric acid |
| title | Nano‐Octahedron Cobalt Oxide Decorated Graphene Nanocomposites for the Selective/Simultaneous Detection of Dopamine |
| title_full | Nano‐Octahedron Cobalt Oxide Decorated Graphene Nanocomposites for the Selective/Simultaneous Detection of Dopamine |
| title_fullStr | Nano‐Octahedron Cobalt Oxide Decorated Graphene Nanocomposites for the Selective/Simultaneous Detection of Dopamine |
| title_full_unstemmed | Nano‐Octahedron Cobalt Oxide Decorated Graphene Nanocomposites for the Selective/Simultaneous Detection of Dopamine |
| title_short | Nano‐Octahedron Cobalt Oxide Decorated Graphene Nanocomposites for the Selective/Simultaneous Detection of Dopamine |
| title_sort | nano octahedron cobalt oxide decorated graphene nanocomposites for the selective simultaneous detection of dopamine |
| topic | Co3O4 dopamine DPV graphene uric acid |
| url | https://doi.org/10.1002/admi.202400981 |
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