Clot Formation in the Sipunculid Worm Themiste petricola: A Haemostatic and Immune Cellular Response
Clot formation in the sipunculid Themiste petricola, a coelomate nonsegmented marine worm without a circulatory system, is a cellular response that creates a haemostatic mass upon activation with sea water. The mass with sealing properties is brought about by homotypic aggregation of granular leukoc...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | International Journal of Cell Biology |
| Online Access: | http://dx.doi.org/10.1155/2012/280675 |
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| author | Tomás Lombardo Guillermo A. Blanco |
| author_facet | Tomás Lombardo Guillermo A. Blanco |
| author_sort | Tomás Lombardo |
| collection | DOAJ |
| description | Clot formation in the sipunculid Themiste petricola, a coelomate nonsegmented marine worm without a circulatory system, is a cellular response that creates a haemostatic mass upon activation with sea water. The mass with sealing properties is brought about by homotypic aggregation of granular leukocytes present in the coelomic fluid that undergo a rapid process of fusion and cell death forming a homogenous clot or mass. The clot structure appears to be stabilized by abundant F-actin that creates a fibrous scaffold retaining cell-derived components. Since preservation of fluid within the coelom is vital for the worm, clotting contributes to rapidly seal the body wall and entrap pathogens upon injury, creating a matrix where wound healing can take place in a second stage. During formation of the clot, microbes or small particles are entrapped. Phagocytosis of self and non-self particles shed from the clot occurs at the clot neighbourhood, demonstrating that clotting is the initial phase of a well-orchestrated dual haemostatic and immune cellular response. |
| format | Article |
| id | doaj-art-6607d90cb0b84f91bfbb412d4b87cdd7 |
| institution | Kabale University |
| issn | 1687-8876 1687-8884 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Cell Biology |
| spelling | doaj-art-6607d90cb0b84f91bfbb412d4b87cdd72025-02-03T06:12:18ZengWileyInternational Journal of Cell Biology1687-88761687-88842012-01-01201210.1155/2012/280675280675Clot Formation in the Sipunculid Worm Themiste petricola: A Haemostatic and Immune Cellular ResponseTomás Lombardo0Guillermo A. Blanco1Laboratorio de Inmunotoxicologia (LaITO), IDEHU, CONICET, Hospital de Clínicas “José de San Martín", Universidad de Buenos Aires (UBA), Avenida Córdoba 2351 Piso 2, Buenos Aires CP 1120, ArgentinaLaboratorio de Inmunotoxicologia (LaITO), IDEHU, CONICET, Hospital de Clínicas “José de San Martín", Universidad de Buenos Aires (UBA), Avenida Córdoba 2351 Piso 2, Buenos Aires CP 1120, ArgentinaClot formation in the sipunculid Themiste petricola, a coelomate nonsegmented marine worm without a circulatory system, is a cellular response that creates a haemostatic mass upon activation with sea water. The mass with sealing properties is brought about by homotypic aggregation of granular leukocytes present in the coelomic fluid that undergo a rapid process of fusion and cell death forming a homogenous clot or mass. The clot structure appears to be stabilized by abundant F-actin that creates a fibrous scaffold retaining cell-derived components. Since preservation of fluid within the coelom is vital for the worm, clotting contributes to rapidly seal the body wall and entrap pathogens upon injury, creating a matrix where wound healing can take place in a second stage. During formation of the clot, microbes or small particles are entrapped. Phagocytosis of self and non-self particles shed from the clot occurs at the clot neighbourhood, demonstrating that clotting is the initial phase of a well-orchestrated dual haemostatic and immune cellular response.http://dx.doi.org/10.1155/2012/280675 |
| spellingShingle | Tomás Lombardo Guillermo A. Blanco Clot Formation in the Sipunculid Worm Themiste petricola: A Haemostatic and Immune Cellular Response International Journal of Cell Biology |
| title | Clot Formation in the Sipunculid Worm Themiste petricola: A Haemostatic and Immune Cellular Response |
| title_full | Clot Formation in the Sipunculid Worm Themiste petricola: A Haemostatic and Immune Cellular Response |
| title_fullStr | Clot Formation in the Sipunculid Worm Themiste petricola: A Haemostatic and Immune Cellular Response |
| title_full_unstemmed | Clot Formation in the Sipunculid Worm Themiste petricola: A Haemostatic and Immune Cellular Response |
| title_short | Clot Formation in the Sipunculid Worm Themiste petricola: A Haemostatic and Immune Cellular Response |
| title_sort | clot formation in the sipunculid worm themiste petricola a haemostatic and immune cellular response |
| url | http://dx.doi.org/10.1155/2012/280675 |
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