Polarity Determinants in Dendritic Spine Development and Plasticity
The asymmetric distribution of various proteins and RNAs is essential for all stages of animal development, and establishment and maintenance of this cellular polarity are regulated by a group of conserved polarity determinants. Studies over the last 10 years highlight important functions for polari...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2016/3145019 |
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| author | Huaye Zhang |
| author_facet | Huaye Zhang |
| author_sort | Huaye Zhang |
| collection | DOAJ |
| description | The asymmetric distribution of various proteins and RNAs is essential for all stages of animal development, and establishment and maintenance of this cellular polarity are regulated by a group of conserved polarity determinants. Studies over the last 10 years highlight important functions for polarity proteins, including apical-basal polarity and planar cell polarity regulators, in dendritic spine development and plasticity. Remarkably, many of the conserved polarity machineries function in similar manners in the context of spine development as they do in epithelial morphogenesis. Interestingly, some polarity proteins also utilize neuronal-specific mechanisms. Although many questions remain unanswered in our understanding of how polarity proteins regulate spine development and plasticity, current and future research will undoubtedly shed more light on how this conserved group of proteins orchestrates different pathways to shape the neuronal circuitry. |
| format | Article |
| id | doaj-art-660674c24db04a1e880de814ec4b6ad5 |
| institution | Kabale University |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-660674c24db04a1e880de814ec4b6ad52025-02-03T01:08:00ZengWileyNeural Plasticity2090-59041687-54432016-01-01201610.1155/2016/31450193145019Polarity Determinants in Dendritic Spine Development and PlasticityHuaye Zhang0Department of Neuroscience and Cell Biology, Rutgers Robert Wood Johnson Medical School, Piscataway, NJ 08854, USAThe asymmetric distribution of various proteins and RNAs is essential for all stages of animal development, and establishment and maintenance of this cellular polarity are regulated by a group of conserved polarity determinants. Studies over the last 10 years highlight important functions for polarity proteins, including apical-basal polarity and planar cell polarity regulators, in dendritic spine development and plasticity. Remarkably, many of the conserved polarity machineries function in similar manners in the context of spine development as they do in epithelial morphogenesis. Interestingly, some polarity proteins also utilize neuronal-specific mechanisms. Although many questions remain unanswered in our understanding of how polarity proteins regulate spine development and plasticity, current and future research will undoubtedly shed more light on how this conserved group of proteins orchestrates different pathways to shape the neuronal circuitry.http://dx.doi.org/10.1155/2016/3145019 |
| spellingShingle | Huaye Zhang Polarity Determinants in Dendritic Spine Development and Plasticity Neural Plasticity |
| title | Polarity Determinants in Dendritic Spine Development and Plasticity |
| title_full | Polarity Determinants in Dendritic Spine Development and Plasticity |
| title_fullStr | Polarity Determinants in Dendritic Spine Development and Plasticity |
| title_full_unstemmed | Polarity Determinants in Dendritic Spine Development and Plasticity |
| title_short | Polarity Determinants in Dendritic Spine Development and Plasticity |
| title_sort | polarity determinants in dendritic spine development and plasticity |
| url | http://dx.doi.org/10.1155/2016/3145019 |
| work_keys_str_mv | AT huayezhang polaritydeterminantsindendriticspinedevelopmentandplasticity |