The Risk Factors of Acquiring Severe Hand, Foot, and Mouth Disease: A Meta-Analysis
Objectives. The incidence of severe hand, foot, and mouth disease (HFMD) is not low, especially in mainland China in almost every year recently. In this study, we conducted a meta-analysis to generate large-scale evidence on the risk factors of severe HFMD to provide suggestions on prevention and co...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Canadian Journal of Infectious Diseases and Medical Microbiology |
| Online Access: | http://dx.doi.org/10.1155/2018/2751457 |
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| author | Bai Jun Sun Hui Jie Chen Ye Chen Xiang Dong An Bao Sen Zhou |
| author_facet | Bai Jun Sun Hui Jie Chen Ye Chen Xiang Dong An Bao Sen Zhou |
| author_sort | Bai Jun Sun |
| collection | DOAJ |
| description | Objectives. The incidence of severe hand, foot, and mouth disease (HFMD) is not low, especially in mainland China in almost every year recently. In this study, we conducted a meta-analysis to generate large-scale evidence on the risk factors of severe HFMD to provide suggestions on prevention and controlling. Methods. PubMed, Web of Science, Embase, Cochrane Library, China National Knowledge Infrastructure (CNKI), and Wanfang (Chinese) were searched to identify relevant articles. All analyses were performed using Stata 14.0. Results. We conducted a meta-analysis of 11 separate studies. Fever (odds ratio (OR) 7.396, 95% confidence interval (CI) 3.565–15.342), fever for more than 3 days (OR 5.773, 95% CI 4.199–7.939), vomiting (OR 6.023, 95% CI 2.598–13.963), limb trembling (OR 42.348, 95% CI 11.765–152.437), dyspnea (OR 12.869, 95% CI 1.948–85.017), contact with HFMD children (OR 5.326, 95% CI 1.263–22.466), rashes on the hips (OR 1.650, 95% CI 1.303–2.090), pathologic reflexes (OR 3057.064, 95% CI 494.409–19000), Lethargy (OR 31.791, 95% CI 3.369–300.020), convulsions (OR 23.652, 95% CI 1.973–283.592), and EV71 infection (OR 9.056, 95% CI 4.102–19.996) were significantly related to the risk of severe HFMD. We did not find an association between female sex (OR 0.918, 95% CI 0.738–1.142), scatter-lived children (OR 1.347, 95% CI 0.245–7.397), floating population (OR 0.847, 95% CI 0.202–3.549), rash on the hands (OR 0.740, 95% CI 0.292–1.874), rash on the foot (OR 0.905, 95% CI 0.645–1.272), the level of the clinic visited first (below the country level) (OR 5.276, 95% CI 0.781–35.630), breast feeding (OR 0.523, 95% CI 0.167–1.643), and the risk of severe HFMD. Conclusions. Fever, fever for more than 3 days, vomiting, limb trembling, dyspnea, contact with HFMD children, rashes on the hips, pathologic reflexes, lethargy, convulsions, and EV71 infection are risk factors for severe HFMD. |
| format | Article |
| id | doaj-art-6605c2bc404e4274a9b37b399b5d41bc |
| institution | Kabale University |
| issn | 1712-9532 1918-1493 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
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| series | Canadian Journal of Infectious Diseases and Medical Microbiology |
| spelling | doaj-art-6605c2bc404e4274a9b37b399b5d41bc2025-08-20T03:34:17ZengWileyCanadian Journal of Infectious Diseases and Medical Microbiology1712-95321918-14932018-01-01201810.1155/2018/27514572751457The Risk Factors of Acquiring Severe Hand, Foot, and Mouth Disease: A Meta-AnalysisBai Jun Sun0Hui Jie Chen1Ye Chen2Xiang Dong An3Bao Sen Zhou4Department of Epidemiology, China Medical University, Shenyang, Liaoning 110000, ChinaDepartment of Infectious Disease, Shenyang Center for Disease Control and Prevention, Shenyang, Liaoning 110031, ChinaDepartment of Infectious Disease, Shenyang Center for Disease Control and Prevention, Shenyang, Liaoning 110031, ChinaDepartment of Infectious Disease, Shenyang Center for Disease Control and Prevention, Shenyang, Liaoning 110031, ChinaDepartment of Epidemiology, China Medical University, Shenyang, Liaoning 110000, ChinaObjectives. The incidence of severe hand, foot, and mouth disease (HFMD) is not low, especially in mainland China in almost every year recently. In this study, we conducted a meta-analysis to generate large-scale evidence on the risk factors of severe HFMD to provide suggestions on prevention and controlling. Methods. PubMed, Web of Science, Embase, Cochrane Library, China National Knowledge Infrastructure (CNKI), and Wanfang (Chinese) were searched to identify relevant articles. All analyses were performed using Stata 14.0. Results. We conducted a meta-analysis of 11 separate studies. Fever (odds ratio (OR) 7.396, 95% confidence interval (CI) 3.565–15.342), fever for more than 3 days (OR 5.773, 95% CI 4.199–7.939), vomiting (OR 6.023, 95% CI 2.598–13.963), limb trembling (OR 42.348, 95% CI 11.765–152.437), dyspnea (OR 12.869, 95% CI 1.948–85.017), contact with HFMD children (OR 5.326, 95% CI 1.263–22.466), rashes on the hips (OR 1.650, 95% CI 1.303–2.090), pathologic reflexes (OR 3057.064, 95% CI 494.409–19000), Lethargy (OR 31.791, 95% CI 3.369–300.020), convulsions (OR 23.652, 95% CI 1.973–283.592), and EV71 infection (OR 9.056, 95% CI 4.102–19.996) were significantly related to the risk of severe HFMD. We did not find an association between female sex (OR 0.918, 95% CI 0.738–1.142), scatter-lived children (OR 1.347, 95% CI 0.245–7.397), floating population (OR 0.847, 95% CI 0.202–3.549), rash on the hands (OR 0.740, 95% CI 0.292–1.874), rash on the foot (OR 0.905, 95% CI 0.645–1.272), the level of the clinic visited first (below the country level) (OR 5.276, 95% CI 0.781–35.630), breast feeding (OR 0.523, 95% CI 0.167–1.643), and the risk of severe HFMD. Conclusions. Fever, fever for more than 3 days, vomiting, limb trembling, dyspnea, contact with HFMD children, rashes on the hips, pathologic reflexes, lethargy, convulsions, and EV71 infection are risk factors for severe HFMD.http://dx.doi.org/10.1155/2018/2751457 |
| spellingShingle | Bai Jun Sun Hui Jie Chen Ye Chen Xiang Dong An Bao Sen Zhou The Risk Factors of Acquiring Severe Hand, Foot, and Mouth Disease: A Meta-Analysis Canadian Journal of Infectious Diseases and Medical Microbiology |
| title | The Risk Factors of Acquiring Severe Hand, Foot, and Mouth Disease: A Meta-Analysis |
| title_full | The Risk Factors of Acquiring Severe Hand, Foot, and Mouth Disease: A Meta-Analysis |
| title_fullStr | The Risk Factors of Acquiring Severe Hand, Foot, and Mouth Disease: A Meta-Analysis |
| title_full_unstemmed | The Risk Factors of Acquiring Severe Hand, Foot, and Mouth Disease: A Meta-Analysis |
| title_short | The Risk Factors of Acquiring Severe Hand, Foot, and Mouth Disease: A Meta-Analysis |
| title_sort | risk factors of acquiring severe hand foot and mouth disease a meta analysis |
| url | http://dx.doi.org/10.1155/2018/2751457 |
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