Serum Kisspeptin and AMH Levels Are Good References for Precocious Puberty Progression
Aim. The aim of this study was to evaluate the levels of kisspeptin and AMH in children with PT or CPP or controls to provide a reference for diagnosis and prognosis. Methods. 38 Chinese children with central precocious puberty (CPP), 38 Chinese children with premature thelarche (PT), and 75 control...
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2020/3126309 |
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| author | Jiang Xue Wei Song Min Si Chao Sun Kailin Li Wei Wang Shuang Liang Yanfeng Xiao |
| author_facet | Jiang Xue Wei Song Min Si Chao Sun Kailin Li Wei Wang Shuang Liang Yanfeng Xiao |
| author_sort | Jiang Xue |
| collection | DOAJ |
| description | Aim. The aim of this study was to evaluate the levels of kisspeptin and AMH in children with PT or CPP or controls to provide a reference for diagnosis and prognosis. Methods. 38 Chinese children with central precocious puberty (CPP), 38 Chinese children with premature thelarche (PT), and 75 controls were recruited. Results. In CPP girls, AMH levels decreased significantly compared to control girls at T2 stage. Compared with the PT and control groups, AMH is the lowest in girls in the CPP group at T3 stage. Kisspeptin decreased significantly in girls in the PT group and increased significantly in girls in the control group from T2 stage to T3 stage. At T3 stage, kisspeptin was significantly higher in girls in the CPP and control groups than in the PT group. In the control group, kisspeptin was significantly higher in boys than in girls at T2 stage. AMH and height were negatively correlated in the girls group. Conclusions. Kisspeptin and AMH have a unique significance in the auxiliary diagnosis, the differential diagnosis, the treatment, and prognosis of sexual puberty disorder. |
| format | Article |
| id | doaj-art-66032be027c64b8a88b12c4953b1f20d |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-66032be027c64b8a88b12c4953b1f20d2025-02-03T01:28:25ZengWileyInternational Journal of Endocrinology1687-83371687-83452020-01-01202010.1155/2020/31263093126309Serum Kisspeptin and AMH Levels Are Good References for Precocious Puberty ProgressionJiang Xue0Wei Song1Min Si2Chao Sun3Kailin Li4Wei Wang5Shuang Liang6Yanfeng Xiao7Department of Pediatrics, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, ChinaDepartment of Pediatrics, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, ChinaDepartment of Intensive Care Unit, Jinan Central Hospital Affiliated to Shandong First Medical University, Jinan, ChinaDepartment of Central Laboratory, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, ChinaDepartment of Central Laboratory, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, ChinaDepartment of Interventional Medicine, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, ChinaDepartment of Pediatrics, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, ChinaDepartment of Pediatrics, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, ChinaAim. The aim of this study was to evaluate the levels of kisspeptin and AMH in children with PT or CPP or controls to provide a reference for diagnosis and prognosis. Methods. 38 Chinese children with central precocious puberty (CPP), 38 Chinese children with premature thelarche (PT), and 75 controls were recruited. Results. In CPP girls, AMH levels decreased significantly compared to control girls at T2 stage. Compared with the PT and control groups, AMH is the lowest in girls in the CPP group at T3 stage. Kisspeptin decreased significantly in girls in the PT group and increased significantly in girls in the control group from T2 stage to T3 stage. At T3 stage, kisspeptin was significantly higher in girls in the CPP and control groups than in the PT group. In the control group, kisspeptin was significantly higher in boys than in girls at T2 stage. AMH and height were negatively correlated in the girls group. Conclusions. Kisspeptin and AMH have a unique significance in the auxiliary diagnosis, the differential diagnosis, the treatment, and prognosis of sexual puberty disorder.http://dx.doi.org/10.1155/2020/3126309 |
| spellingShingle | Jiang Xue Wei Song Min Si Chao Sun Kailin Li Wei Wang Shuang Liang Yanfeng Xiao Serum Kisspeptin and AMH Levels Are Good References for Precocious Puberty Progression International Journal of Endocrinology |
| title | Serum Kisspeptin and AMH Levels Are Good References for Precocious Puberty Progression |
| title_full | Serum Kisspeptin and AMH Levels Are Good References for Precocious Puberty Progression |
| title_fullStr | Serum Kisspeptin and AMH Levels Are Good References for Precocious Puberty Progression |
| title_full_unstemmed | Serum Kisspeptin and AMH Levels Are Good References for Precocious Puberty Progression |
| title_short | Serum Kisspeptin and AMH Levels Are Good References for Precocious Puberty Progression |
| title_sort | serum kisspeptin and amh levels are good references for precocious puberty progression |
| url | http://dx.doi.org/10.1155/2020/3126309 |
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