Protocol and design of the REPOSE study: a double-blinded, randomised, placebo-controlled trial to evaluate the efficacy of suvorexant to improve postoperative sleep and reduce delirium severity in older patients undergoing non-cardiac surgery

Protocol and design of the REPOSE study: a double-blinded, randomised, placebo-controlled trial to evaluate the efficacy of suvorexant to improve postoperative sleep and reduce delirium severity in older patients undergoing non-cardiac surgery

Introduction Postoperative delirium occurs in up to 40% of older surgical patients and has been associated with prolonged hospital stays, long-term cognitive impairment and increased 1-year postoperative mortality. Postoperative sleep disturbances may increase the risk of delirium, but studies inves...

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Main Authors: Karthik Raghunathan, John Michael Fallon, Mona Hashemaghaie, Christy E Peterson, Dieplinh Tran, Sophie R Wu, Jonathan M Valdes, Nicole M Pedicini, Melissa E Adams, Marjorie Soltis, Wissam Mansour, Mary Cooter Wright, Miriam M Treggiari, Cina Sasannejad, Michael J Devinney
Format: Article
Language:English
Published: BMJ Publishing Group 2025-03-01
Series:BMJ Open
Online Access:https://bmjopen.bmj.com/content/15/3/e091099.full
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