Th1/Th2 Balance and Th17/Treg-Mediated Immunity in relation to Murine Resistance to Dextran Sulfate-Induced Colitis
Background. The role of the Th17/Treg balance in the development of experimental colitis remains poorly understood. Methods. We exploited the differential response of BALB/c mice and C57BL/6 mice towards drinking water mediated by dextran sulfate sodium (DSS) challenge. Results. DSS-resistant BALB/c...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2017/7047201 |
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| author | Fangli Yang Danan Wang Yan Li Lixuan Sang Junfeng Zhu Jinyan Wang Bing Wei Changlong Lu Xun Sun |
| author_facet | Fangli Yang Danan Wang Yan Li Lixuan Sang Junfeng Zhu Jinyan Wang Bing Wei Changlong Lu Xun Sun |
| author_sort | Fangli Yang |
| collection | DOAJ |
| description | Background. The role of the Th17/Treg balance in the development of experimental colitis remains poorly understood. Methods. We exploited the differential response of BALB/c mice and C57BL/6 mice towards drinking water mediated by dextran sulfate sodium (DSS) challenge. Results. DSS-resistant BALB/c mice were characterized by low levels of IFN-γ and TNF-α but high levels of IL-4, IL-6, IL-10, IL-17A, IL-17F, and colon lamina propria and mesenteric lymph node (MLN) CD4+CD25+FoxP3+ T cells when compared to C57BL/6 mice. Collectively, these data indicate the propensity of BALB/c mice towards a Th2/Th17/Treg-polarized immunity protecting these animals against DSS challenge, whereas Th1-polarization of C57BL/6 mice confers sensitivity to DSS-induced colitis. Conclusions. The intrinsic congenital capacity of mouse strains with respect to T cell proliferation determines sensitivity to experimental colitis. |
| format | Article |
| id | doaj-art-65fc701d62894d7b8370e651df851042 |
| institution | OA Journals |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-65fc701d62894d7b8370e651df8510422025-08-20T02:23:46ZengWileyJournal of Immunology Research2314-88612314-71562017-01-01201710.1155/2017/70472017047201Th1/Th2 Balance and Th17/Treg-Mediated Immunity in relation to Murine Resistance to Dextran Sulfate-Induced ColitisFangli Yang0Danan Wang1Yan Li2Lixuan Sang3Junfeng Zhu4Jinyan Wang5Bing Wei6Changlong Lu7Xun Sun8Department of Immunology, China Medical University, Shenyang 110122, ChinaDepartment of Immunology, China Medical University, Shenyang 110122, ChinaDepartment of Immunology, China Medical University, Shenyang 110122, ChinaDepartment of Immunology, China Medical University, Shenyang 110122, ChinaDepartment of Immunology, China Medical University, Shenyang 110122, ChinaDepartment of Immunology, China Medical University, Shenyang 110122, ChinaDepartment of Immunology, China Medical University, Shenyang 110122, ChinaDepartment of Immunology, China Medical University, Shenyang 110122, ChinaDepartment of Immunology, China Medical University, Shenyang 110122, ChinaBackground. The role of the Th17/Treg balance in the development of experimental colitis remains poorly understood. Methods. We exploited the differential response of BALB/c mice and C57BL/6 mice towards drinking water mediated by dextran sulfate sodium (DSS) challenge. Results. DSS-resistant BALB/c mice were characterized by low levels of IFN-γ and TNF-α but high levels of IL-4, IL-6, IL-10, IL-17A, IL-17F, and colon lamina propria and mesenteric lymph node (MLN) CD4+CD25+FoxP3+ T cells when compared to C57BL/6 mice. Collectively, these data indicate the propensity of BALB/c mice towards a Th2/Th17/Treg-polarized immunity protecting these animals against DSS challenge, whereas Th1-polarization of C57BL/6 mice confers sensitivity to DSS-induced colitis. Conclusions. The intrinsic congenital capacity of mouse strains with respect to T cell proliferation determines sensitivity to experimental colitis.http://dx.doi.org/10.1155/2017/7047201 |
| spellingShingle | Fangli Yang Danan Wang Yan Li Lixuan Sang Junfeng Zhu Jinyan Wang Bing Wei Changlong Lu Xun Sun Th1/Th2 Balance and Th17/Treg-Mediated Immunity in relation to Murine Resistance to Dextran Sulfate-Induced Colitis Journal of Immunology Research |
| title | Th1/Th2 Balance and Th17/Treg-Mediated Immunity in relation to Murine Resistance to Dextran Sulfate-Induced Colitis |
| title_full | Th1/Th2 Balance and Th17/Treg-Mediated Immunity in relation to Murine Resistance to Dextran Sulfate-Induced Colitis |
| title_fullStr | Th1/Th2 Balance and Th17/Treg-Mediated Immunity in relation to Murine Resistance to Dextran Sulfate-Induced Colitis |
| title_full_unstemmed | Th1/Th2 Balance and Th17/Treg-Mediated Immunity in relation to Murine Resistance to Dextran Sulfate-Induced Colitis |
| title_short | Th1/Th2 Balance and Th17/Treg-Mediated Immunity in relation to Murine Resistance to Dextran Sulfate-Induced Colitis |
| title_sort | th1 th2 balance and th17 treg mediated immunity in relation to murine resistance to dextran sulfate induced colitis |
| url | http://dx.doi.org/10.1155/2017/7047201 |
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