Versatile Porphyrin Arrangements for Photodynamic Therapy—A Review
Nanotechnology is an emerging field that involves the development of nanoscale particles, their fabrication methods, and potential applications. From nanosized inorganic particles to biopolymers, the variety of nanoparticles is unstoppably growing, offering huge opportunities for drug delivery. Vari...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2024-11-01
|
| Series: | Nanomaterials |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2079-4991/14/23/1879 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850107096490573824 |
|---|---|
| author | Arleta Glowacka-Sobotta Beata Czarczynska-Goslinska Daniel Ziental Marcin Wysocki Maciej Michalak Emre Güzel Lukasz Sobotta |
| author_facet | Arleta Glowacka-Sobotta Beata Czarczynska-Goslinska Daniel Ziental Marcin Wysocki Maciej Michalak Emre Güzel Lukasz Sobotta |
| author_sort | Arleta Glowacka-Sobotta |
| collection | DOAJ |
| description | Nanotechnology is an emerging field that involves the development of nanoscale particles, their fabrication methods, and potential applications. From nanosized inorganic particles to biopolymers, the variety of nanoparticles is unstoppably growing, offering huge opportunities for drug delivery. Various nanoformulations, such as nanoparticles, nanocomposites, and nanoemulsions, have been developed to enhance drug stability, solubility, and tissue penetration. Moreover, nanocarriers can be specifically engineered to target diseased cells or release the drug in a controllable manner, minimizing damage to surrounding healthy tissues and reducing side effects. This review focuses on the combinations between porphyrin derivatives and nanocarriers applied in photodynamic therapy (PDT). PDT has emerged as a significant advance in medicine, offering a low-invasive method for managing infections, the treatment of tumors, and various dermatoses. The therapy relies on the activation of a photosensitizer by light, which results in the generation of reactive oxygen species. Despite their favorable properties, porphyrins reveal non-specific distribution within the body. Nanotechnology has the capability to enhance the PS delivery and its activation. This review explores the potential improvements that are provided by the use of nanotechnology in the PDT field. |
| format | Article |
| id | doaj-art-65f2ea6600b14c8d960b87e670c3ac7b |
| institution | OA Journals |
| issn | 2079-4991 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nanomaterials |
| spelling | doaj-art-65f2ea6600b14c8d960b87e670c3ac7b2025-08-20T02:38:39ZengMDPI AGNanomaterials2079-49912024-11-011423187910.3390/nano14231879Versatile Porphyrin Arrangements for Photodynamic Therapy—A ReviewArleta Glowacka-Sobotta0Beata Czarczynska-Goslinska1Daniel Ziental2Marcin Wysocki3Maciej Michalak4Emre Güzel5Lukasz Sobotta6Chair and Department of Orthodontics and Temporomandibular Disorders, Poznan University of Medical Sciences, Bukowska 70, 60-812 Poznan, PolandChair and Department of Pharmaceutical Technology, Poznan University of Medical Sciences, Rokietnicka 3, 60-806 Poznan, PolandChair and Department of Inorganic and Analytical Chemistry, Poznan University of Medical Sciences, Rokietnicka 3, 60-806 Poznan, PolandChair and Department of Inorganic and Analytical Chemistry, Poznan University of Medical Sciences, Rokietnicka 3, 60-806 Poznan, PolandChair and Department of Inorganic and Analytical Chemistry, Poznan University of Medical Sciences, Rokietnicka 3, 60-806 Poznan, PolandDepartment of Engineering Fundamental Sciences, Sakarya University of Applied Sciences, 54050 Sakarya, TürkiyeChair and Department of Inorganic and Analytical Chemistry, Poznan University of Medical Sciences, Rokietnicka 3, 60-806 Poznan, PolandNanotechnology is an emerging field that involves the development of nanoscale particles, their fabrication methods, and potential applications. From nanosized inorganic particles to biopolymers, the variety of nanoparticles is unstoppably growing, offering huge opportunities for drug delivery. Various nanoformulations, such as nanoparticles, nanocomposites, and nanoemulsions, have been developed to enhance drug stability, solubility, and tissue penetration. Moreover, nanocarriers can be specifically engineered to target diseased cells or release the drug in a controllable manner, minimizing damage to surrounding healthy tissues and reducing side effects. This review focuses on the combinations between porphyrin derivatives and nanocarriers applied in photodynamic therapy (PDT). PDT has emerged as a significant advance in medicine, offering a low-invasive method for managing infections, the treatment of tumors, and various dermatoses. The therapy relies on the activation of a photosensitizer by light, which results in the generation of reactive oxygen species. Despite their favorable properties, porphyrins reveal non-specific distribution within the body. Nanotechnology has the capability to enhance the PS delivery and its activation. This review explores the potential improvements that are provided by the use of nanotechnology in the PDT field.https://www.mdpi.com/2079-4991/14/23/1879PDTPACTporphyrinnanotechnologybacterial infectionschlorin e6 |
| spellingShingle | Arleta Glowacka-Sobotta Beata Czarczynska-Goslinska Daniel Ziental Marcin Wysocki Maciej Michalak Emre Güzel Lukasz Sobotta Versatile Porphyrin Arrangements for Photodynamic Therapy—A Review Nanomaterials PDT PACT porphyrin nanotechnology bacterial infections chlorin e6 |
| title | Versatile Porphyrin Arrangements for Photodynamic Therapy—A Review |
| title_full | Versatile Porphyrin Arrangements for Photodynamic Therapy—A Review |
| title_fullStr | Versatile Porphyrin Arrangements for Photodynamic Therapy—A Review |
| title_full_unstemmed | Versatile Porphyrin Arrangements for Photodynamic Therapy—A Review |
| title_short | Versatile Porphyrin Arrangements for Photodynamic Therapy—A Review |
| title_sort | versatile porphyrin arrangements for photodynamic therapy a review |
| topic | PDT PACT porphyrin nanotechnology bacterial infections chlorin e6 |
| url | https://www.mdpi.com/2079-4991/14/23/1879 |
| work_keys_str_mv | AT arletaglowackasobotta versatileporphyrinarrangementsforphotodynamictherapyareview AT beataczarczynskagoslinska versatileporphyrinarrangementsforphotodynamictherapyareview AT danielziental versatileporphyrinarrangementsforphotodynamictherapyareview AT marcinwysocki versatileporphyrinarrangementsforphotodynamictherapyareview AT maciejmichalak versatileporphyrinarrangementsforphotodynamictherapyareview AT emreguzel versatileporphyrinarrangementsforphotodynamictherapyareview AT lukaszsobotta versatileporphyrinarrangementsforphotodynamictherapyareview |