Hypotheses of development and strategies for overcoming drug resistance in epilepsy. Part I: Hypotheses of development
Currently, the problem of effective therapy for drug-resistant epilepsy remains vastly relevant. The severity of drug-resistant epilepsy, remarkable negative social sequelae and sudden death in epilepsy pose a heavy burden on healthcare system. Although many innovative antiepileptic drugs have been...
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| Format: | Article |
| Language: | Russian |
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IRBIS LLC
2025-01-01
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| Series: | Эпилепсия и пароксизмальные состояния |
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| Online Access: | https://www.epilepsia.su/jour/article/view/1150 |
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| author | A. M. Yakimov E. E. Timechko A. I. Paramonova A. A. Vasilieva F. K. Rybachenko A. D. Rybachenko D. V. Dmitrenko |
| author_facet | A. M. Yakimov E. E. Timechko A. I. Paramonova A. A. Vasilieva F. K. Rybachenko A. D. Rybachenko D. V. Dmitrenko |
| author_sort | A. M. Yakimov |
| collection | DOAJ |
| description | Currently, the problem of effective therapy for drug-resistant epilepsy remains vastly relevant. The severity of drug-resistant epilepsy, remarkable negative social sequelae and sudden death in epilepsy pose a heavy burden on healthcare system. Although many innovative antiepileptic drugs have been developed in recent decades, surgical approach remains the only effective way to treat drug-resistant epilepsy which is coupled to significant health risks and does not guarantee freedom from seizures. The stumbling block in managing this pathology is the lack of knowledge on pathogenetic mechanisms, leaving a significant proportion of patients without quality medical care. There are different viewpoints on developing drug resistance in epilepsy, which are characterized by multilayered and overlapping molecular disease bases. The review presents the analysis of the existing hypotheses regarding the mechanisms underlying drug resistance development in epilepsy. |
| format | Article |
| id | doaj-art-65ed6d6d382b43f28e56fd5209eb107b |
| institution | DOAJ |
| issn | 2077-8333 2311-4088 |
| language | Russian |
| publishDate | 2025-01-01 |
| publisher | IRBIS LLC |
| record_format | Article |
| series | Эпилепсия и пароксизмальные состояния |
| spelling | doaj-art-65ed6d6d382b43f28e56fd5209eb107b2025-08-20T03:18:59ZrusIRBIS LLCЭпилепсия и пароксизмальные состояния2077-83332311-40882025-01-0116437538410.17749/2077-8333/epi.par.con.2024.210666Hypotheses of development and strategies for overcoming drug resistance in epilepsy. Part I: Hypotheses of developmentA. M. Yakimov0E. E. Timechko1A. I. Paramonova2A. A. Vasilieva3F. K. Rybachenko4A. D. Rybachenko5D. V. Dmitrenko6Voino-Yasenetsky Krasnoyarsk State Medical UniversityVoino-Yasenetsky Krasnoyarsk State Medical UniversityVoino-Yasenetsky Krasnoyarsk State Medical UniversityVoino-Yasenetsky Krasnoyarsk State Medical UniversityVoino-Yasenetsky Krasnoyarsk State Medical UniversityVoino-Yasenetsky Krasnoyarsk State Medical UniversityVoino-Yasenetsky Krasnoyarsk State Medical UniversityCurrently, the problem of effective therapy for drug-resistant epilepsy remains vastly relevant. The severity of drug-resistant epilepsy, remarkable negative social sequelae and sudden death in epilepsy pose a heavy burden on healthcare system. Although many innovative antiepileptic drugs have been developed in recent decades, surgical approach remains the only effective way to treat drug-resistant epilepsy which is coupled to significant health risks and does not guarantee freedom from seizures. The stumbling block in managing this pathology is the lack of knowledge on pathogenetic mechanisms, leaving a significant proportion of patients without quality medical care. There are different viewpoints on developing drug resistance in epilepsy, which are characterized by multilayered and overlapping molecular disease bases. The review presents the analysis of the existing hypotheses regarding the mechanisms underlying drug resistance development in epilepsy.https://www.epilepsia.su/jour/article/view/1150drug-resistant epilepsydrug resistance mechanismsp-glycoproteinchannelopathiesneuroinflammationneural network |
| spellingShingle | A. M. Yakimov E. E. Timechko A. I. Paramonova A. A. Vasilieva F. K. Rybachenko A. D. Rybachenko D. V. Dmitrenko Hypotheses of development and strategies for overcoming drug resistance in epilepsy. Part I: Hypotheses of development Эпилепсия и пароксизмальные состояния drug-resistant epilepsy drug resistance mechanisms p-glycoprotein channelopathies neuroinflammation neural network |
| title | Hypotheses of development and strategies for overcoming drug resistance in epilepsy. Part I: Hypotheses of development |
| title_full | Hypotheses of development and strategies for overcoming drug resistance in epilepsy. Part I: Hypotheses of development |
| title_fullStr | Hypotheses of development and strategies for overcoming drug resistance in epilepsy. Part I: Hypotheses of development |
| title_full_unstemmed | Hypotheses of development and strategies for overcoming drug resistance in epilepsy. Part I: Hypotheses of development |
| title_short | Hypotheses of development and strategies for overcoming drug resistance in epilepsy. Part I: Hypotheses of development |
| title_sort | hypotheses of development and strategies for overcoming drug resistance in epilepsy part i hypotheses of development |
| topic | drug-resistant epilepsy drug resistance mechanisms p-glycoprotein channelopathies neuroinflammation neural network |
| url | https://www.epilepsia.su/jour/article/view/1150 |
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