Targeting CDK4/6 in Cancer: Molecular Docking and Cytotoxic Evaluation of <i>Thottea siliquosa</i> Root Extract

Targeting CDK4/6 in Cancer: Molecular Docking and Cytotoxic Evaluation of <i>Thottea siliquosa</i> Root Extract

<b>Background</b>: Cyclin-dependent kinases 4 and 6 (CDK4/6) are pivotal regulators of the cell cycle, whose dysregulation is closely linked to cancer progression. While synthetic CDK4/6 inhibitors such as Palbociclib and Ribociclib are clinically effective, their use is limited by signi...

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Bibliographic Details
Main Authors: Maruthamuthu Rathinam Elakkiya, Mohandas Krishnasreya, Sureshkumar Tharani, Muthukrishnan Arun, L. Vijayalakshmi, Jiseok Lim, Ayman A. Ghfar, Balasundaramsaraswathy Chithradevi
Format: Article
Language:English
Published: MDPI AG 2025-07-01
Series:Biomedicines
Subjects:
<i>Thottea siliquosa</i>
CDK4/6 inhibition
molecular docking
ADME profiling
cytotoxicity
cell migration
Online Access:https://www.mdpi.com/2227-9059/13/7/1658
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