Relationship between Central Arterial Stiffness and Insulin Resistance in Chinese Community-Dwelling Population without Diabetes Mellitus
Objective. Insulin resistance (IR) is a pathological condition present not only in patients with type 2 diabetes mellitus (DM), but also in community-dwelling population without DM. Both central arterial stiffness and IR are closely correlated with cardiovascular morbidity and mortality. The relatio...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2017/1073919 |
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| author | Shihui Fu Ying Lin Leiming Luo Ping Ye |
| author_facet | Shihui Fu Ying Lin Leiming Luo Ping Ye |
| author_sort | Shihui Fu |
| collection | DOAJ |
| description | Objective. Insulin resistance (IR) is a pathological condition present not only in patients with type 2 diabetes mellitus (DM), but also in community-dwelling population without DM. Both central arterial stiffness and IR are closely correlated with cardiovascular morbidity and mortality. The relationship between central arterial stiffness and IR has not been described in Chinese community-dwelling population without DM. The current analysis was designed to investigate the relationship between central arterial stiffness and IR in Chinese community-dwelling population without DM. Methods. There were 1150 participants fully assessed for not only homeostasis model assessment of insulin resistance (HOMA-IR) but also carotid-femoral pulse wave velocity (cfPWV). Results. Median age was 39 (18–80) years, and 69.7% were men. Bivariate correlation analysis showed that cfPWV was significantly related to HOMA-IR (P<0.05). Logistic regression analysis indicated that cfPWV was independently associated with HOMA-IR (P<0.05). Conclusions. This community-based analysis testified that the relationship between central arterial stiffness and IR was evident as early as during nondiabetic stage. Early interventions in Chinese community-dwelling population without DM to improve the IR are also important in the prevention of cardiovascular diseases. |
| format | Article |
| id | doaj-art-65e5c0a405db4e2db1edf62cc6882d44 |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-65e5c0a405db4e2db1edf62cc6882d442025-08-20T03:34:17ZengWileyInternational Journal of Endocrinology1687-83371687-83452017-01-01201710.1155/2017/10739191073919Relationship between Central Arterial Stiffness and Insulin Resistance in Chinese Community-Dwelling Population without Diabetes MellitusShihui Fu0Ying Lin1Leiming Luo2Ping Ye3Department of Geriatric Cardiology, Chinese People’s Liberation Army General Hospital, Beijing, ChinaDepartment of Cardiology and Hainan Branch, Chinese People’s Liberation Army General Hospital, Beijing, ChinaDepartment of Geriatric Cardiology, Chinese People’s Liberation Army General Hospital, Beijing, ChinaDepartment of Geriatric Cardiology, Chinese People’s Liberation Army General Hospital, Beijing, ChinaObjective. Insulin resistance (IR) is a pathological condition present not only in patients with type 2 diabetes mellitus (DM), but also in community-dwelling population without DM. Both central arterial stiffness and IR are closely correlated with cardiovascular morbidity and mortality. The relationship between central arterial stiffness and IR has not been described in Chinese community-dwelling population without DM. The current analysis was designed to investigate the relationship between central arterial stiffness and IR in Chinese community-dwelling population without DM. Methods. There were 1150 participants fully assessed for not only homeostasis model assessment of insulin resistance (HOMA-IR) but also carotid-femoral pulse wave velocity (cfPWV). Results. Median age was 39 (18–80) years, and 69.7% were men. Bivariate correlation analysis showed that cfPWV was significantly related to HOMA-IR (P<0.05). Logistic regression analysis indicated that cfPWV was independently associated with HOMA-IR (P<0.05). Conclusions. This community-based analysis testified that the relationship between central arterial stiffness and IR was evident as early as during nondiabetic stage. Early interventions in Chinese community-dwelling population without DM to improve the IR are also important in the prevention of cardiovascular diseases.http://dx.doi.org/10.1155/2017/1073919 |
| spellingShingle | Shihui Fu Ying Lin Leiming Luo Ping Ye Relationship between Central Arterial Stiffness and Insulin Resistance in Chinese Community-Dwelling Population without Diabetes Mellitus International Journal of Endocrinology |
| title | Relationship between Central Arterial Stiffness and Insulin Resistance in Chinese Community-Dwelling Population without Diabetes Mellitus |
| title_full | Relationship between Central Arterial Stiffness and Insulin Resistance in Chinese Community-Dwelling Population without Diabetes Mellitus |
| title_fullStr | Relationship between Central Arterial Stiffness and Insulin Resistance in Chinese Community-Dwelling Population without Diabetes Mellitus |
| title_full_unstemmed | Relationship between Central Arterial Stiffness and Insulin Resistance in Chinese Community-Dwelling Population without Diabetes Mellitus |
| title_short | Relationship between Central Arterial Stiffness and Insulin Resistance in Chinese Community-Dwelling Population without Diabetes Mellitus |
| title_sort | relationship between central arterial stiffness and insulin resistance in chinese community dwelling population without diabetes mellitus |
| url | http://dx.doi.org/10.1155/2017/1073919 |
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