Evolution of an agriculture-associated disease causing Campylobacter coli clade: evidence from national surveillance data in Scotland.
The common zoonotic pathogen Campylobacter coli is an important cause of bacterial gastroenteritis worldwide but its evolution is incompletely understood. Using multilocus sequence type (MLST) data of 7 housekeeping genes from a national survey of Campylobacter in Scotland (2005/6), and a combined p...
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Public Library of Science (PLoS)
2010-12-01
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| Online Access: | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0015708&type=printable |
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| author | Samuel K Sheppard John F Dallas Daniel J Wilson Norval J C Strachan Noel D McCarthy Keith A Jolley Frances M Colles Ovidiu Rotariu Iain D Ogden Ken J Forbes Martin C J Maiden |
| author_facet | Samuel K Sheppard John F Dallas Daniel J Wilson Norval J C Strachan Noel D McCarthy Keith A Jolley Frances M Colles Ovidiu Rotariu Iain D Ogden Ken J Forbes Martin C J Maiden |
| author_sort | Samuel K Sheppard |
| collection | DOAJ |
| description | The common zoonotic pathogen Campylobacter coli is an important cause of bacterial gastroenteritis worldwide but its evolution is incompletely understood. Using multilocus sequence type (MLST) data of 7 housekeeping genes from a national survey of Campylobacter in Scotland (2005/6), and a combined population genetic-phylogenetics approach, we investigated the evolutionary history of C. coli. Genealogical reconstruction of isolates from clinical infection, farm animals and the environment, revealed a three-clade genetic structure. The majority of farm animal, and all disease causing genotypes belonged to a single clade (clade 1) which had comparatively low synonymous sequence diversity, little deep branching genetic structure, and a higher number of shared alleles providing evidence of recent clonal decent. Calibration of the rate of molecular evolution, based on within-species genetic variation, estimated a more rapid rate of evolution than in traditional estimates. This placed the divergence of the clades at less than 2500 years ago, consistent with the introduction of an agricultural niche having had an effect upon the evolution of the C. coli clades. Attribution of clinical isolate genotypes to source, using an asymmetric island model, confirmed that strains from chicken and ruminants, and not pigs or turkeys, are the principal source of human C. coli infection. Taken together these analyses are consistent with an evolutionary scenario describing the emergence of agriculture-associated C. coli lineage that is an important human pathogen. |
| format | Article |
| id | doaj-art-65e152b577c24eb0adde0c77089e93a6 |
| institution | DOAJ |
| issn | 1932-6203 |
| language | English |
| publishDate | 2010-12-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj-art-65e152b577c24eb0adde0c77089e93a62025-08-20T03:19:53ZengPublic Library of Science (PLoS)PLoS ONE1932-62032010-12-01512e1570810.1371/journal.pone.0015708Evolution of an agriculture-associated disease causing Campylobacter coli clade: evidence from national surveillance data in Scotland.Samuel K SheppardJohn F DallasDaniel J WilsonNorval J C StrachanNoel D McCarthyKeith A JolleyFrances M CollesOvidiu RotariuIain D OgdenKen J ForbesMartin C J MaidenThe common zoonotic pathogen Campylobacter coli is an important cause of bacterial gastroenteritis worldwide but its evolution is incompletely understood. Using multilocus sequence type (MLST) data of 7 housekeeping genes from a national survey of Campylobacter in Scotland (2005/6), and a combined population genetic-phylogenetics approach, we investigated the evolutionary history of C. coli. Genealogical reconstruction of isolates from clinical infection, farm animals and the environment, revealed a three-clade genetic structure. The majority of farm animal, and all disease causing genotypes belonged to a single clade (clade 1) which had comparatively low synonymous sequence diversity, little deep branching genetic structure, and a higher number of shared alleles providing evidence of recent clonal decent. Calibration of the rate of molecular evolution, based on within-species genetic variation, estimated a more rapid rate of evolution than in traditional estimates. This placed the divergence of the clades at less than 2500 years ago, consistent with the introduction of an agricultural niche having had an effect upon the evolution of the C. coli clades. Attribution of clinical isolate genotypes to source, using an asymmetric island model, confirmed that strains from chicken and ruminants, and not pigs or turkeys, are the principal source of human C. coli infection. Taken together these analyses are consistent with an evolutionary scenario describing the emergence of agriculture-associated C. coli lineage that is an important human pathogen.https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0015708&type=printable |
| spellingShingle | Samuel K Sheppard John F Dallas Daniel J Wilson Norval J C Strachan Noel D McCarthy Keith A Jolley Frances M Colles Ovidiu Rotariu Iain D Ogden Ken J Forbes Martin C J Maiden Evolution of an agriculture-associated disease causing Campylobacter coli clade: evidence from national surveillance data in Scotland. PLoS ONE |
| title | Evolution of an agriculture-associated disease causing Campylobacter coli clade: evidence from national surveillance data in Scotland. |
| title_full | Evolution of an agriculture-associated disease causing Campylobacter coli clade: evidence from national surveillance data in Scotland. |
| title_fullStr | Evolution of an agriculture-associated disease causing Campylobacter coli clade: evidence from national surveillance data in Scotland. |
| title_full_unstemmed | Evolution of an agriculture-associated disease causing Campylobacter coli clade: evidence from national surveillance data in Scotland. |
| title_short | Evolution of an agriculture-associated disease causing Campylobacter coli clade: evidence from national surveillance data in Scotland. |
| title_sort | evolution of an agriculture associated disease causing campylobacter coli clade evidence from national surveillance data in scotland |
| url | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0015708&type=printable |
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