The retromer complex is required for rhodopsin recycling and its loss leads to photoreceptor degeneration.

The retromer complex is required for rhodopsin recycling and its loss leads to photoreceptor degeneration.

Rhodopsin mistrafficking can cause photoreceptor (PR) degeneration. Upon light exposure, activated rhodopsin 1 (Rh1) in Drosophila PRs is internalized via endocytosis and degraded in lysosomes. Whether internalized Rh1 can be recycled is unknown. Here, we show that the retromer complex is expressed...

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Bibliographic Details
Main Authors: Shiuan Wang, Kai Li Tan, Melina A Agosto, Bo Xiong, Shinya Yamamoto, Hector Sandoval, Manish Jaiswal, Vafa Bayat, Ke Zhang, Wu-Lin Charng, Gabriela David, Lita Duraine, Kartik Venkatachalam, Theodore G Wensel, Hugo J Bellen
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-04-01
Series:PLoS Biology
Online Access:https://journals.plos.org/plosbiology/article/file?id=10.1371/journal.pbio.1001847&type=printable
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