Role of hyperuricemia in diabetic nephropathy
Hyperuricemia (HUA), characterized by abnormal uric acid (UA) metabolism, leads to the accumulation of urate salts within the kidney. This accumulation not only disrupts glomerular filtration and tubular reabsorption functions but also triggers oxidative stress, inflammation,and up-regulating the re...
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| Format: | Article |
| Language: | zho |
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Institute of Basic Medical Sciences and Peking Union Medical College Hospital, Chinese Academy of Medical Sciences / Peking Union Medical College.
2025-03-01
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| Series: | Jichu yixue yu linchuang |
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| Online Access: | https://journal11.magtechjournal.com/Jwk_jcyxylc/fileup/1001-6325/PDF/1001-6325-2025-45-3-281-378.pdf |
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| author | DENG Jie, WEI Jiali |
| author_facet | DENG Jie, WEI Jiali |
| author_sort | DENG Jie, WEI Jiali |
| collection | DOAJ |
| description | Hyperuricemia (HUA), characterized by abnormal uric acid (UA) metabolism, leads to the accumulation of urate salts within the kidney. This accumulation not only disrupts glomerular filtration and tubular reabsorption functions but also triggers oxidative stress, inflammation,and up-regulating the renin-angiotensin-aldosterone system (RASS), all of which damage renal cells and tissues. These mechanisms contribute to renal fibrosis and accelerate the progression of diabetic nephropathy (DN)/diabetic kidney disease(DKD). These findings underscore the role of HUA as a risk factor for the advancement of DKD, emphasizing the critical importance of effective UA control in delaying its development. |
| format | Article |
| id | doaj-art-65dd3b825e964c14a8f9362f87a9c8dd |
| institution | DOAJ |
| issn | 1001-6325 |
| language | zho |
| publishDate | 2025-03-01 |
| publisher | Institute of Basic Medical Sciences and Peking Union Medical College Hospital, Chinese Academy of Medical Sciences / Peking Union Medical College. |
| record_format | Article |
| series | Jichu yixue yu linchuang |
| spelling | doaj-art-65dd3b825e964c14a8f9362f87a9c8dd2025-08-20T02:53:57ZzhoInstitute of Basic Medical Sciences and Peking Union Medical College Hospital, Chinese Academy of Medical Sciences / Peking Union Medical College.Jichu yixue yu linchuang1001-63252025-03-0145337838110.16352/j.issn.1001-6325.2025.03.0378Role of hyperuricemia in diabetic nephropathyDENG Jie, WEI Jiali01. Department of Clinical Medicine, Hainan Medical University, Haikou 518110; ;2. Department of Nephrology, Hainan Hospital Affiliated to Hainan Medical University, Haikou 570311, ChinaHyperuricemia (HUA), characterized by abnormal uric acid (UA) metabolism, leads to the accumulation of urate salts within the kidney. This accumulation not only disrupts glomerular filtration and tubular reabsorption functions but also triggers oxidative stress, inflammation,and up-regulating the renin-angiotensin-aldosterone system (RASS), all of which damage renal cells and tissues. These mechanisms contribute to renal fibrosis and accelerate the progression of diabetic nephropathy (DN)/diabetic kidney disease(DKD). These findings underscore the role of HUA as a risk factor for the advancement of DKD, emphasizing the critical importance of effective UA control in delaying its development.https://journal11.magtechjournal.com/Jwk_jcyxylc/fileup/1001-6325/PDF/1001-6325-2025-45-3-281-378.pdfhyperuricemia|uric acid metabolism|diabetic kidney disease |
| spellingShingle | DENG Jie, WEI Jiali Role of hyperuricemia in diabetic nephropathy Jichu yixue yu linchuang hyperuricemia|uric acid metabolism|diabetic kidney disease |
| title | Role of hyperuricemia in diabetic nephropathy |
| title_full | Role of hyperuricemia in diabetic nephropathy |
| title_fullStr | Role of hyperuricemia in diabetic nephropathy |
| title_full_unstemmed | Role of hyperuricemia in diabetic nephropathy |
| title_short | Role of hyperuricemia in diabetic nephropathy |
| title_sort | role of hyperuricemia in diabetic nephropathy |
| topic | hyperuricemia|uric acid metabolism|diabetic kidney disease |
| url | https://journal11.magtechjournal.com/Jwk_jcyxylc/fileup/1001-6325/PDF/1001-6325-2025-45-3-281-378.pdf |
| work_keys_str_mv | AT dengjieweijiali roleofhyperuricemiaindiabeticnephropathy |