Association between Life’s Crucial 9 and psoriatic arthritis in U.S. adults: a cross-sectional study
BackgroundPsoriatic arthritis (PsA) has been closely associated with an elevated risk of cardiovascular disease (CVD). Nevertheless, the connection between Life’s Crucial 9 (LC9), which serves as a holistic measure of cardiovascular health (CVH), and PsA remains insufficiently studied. This research...
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Frontiers Media S.A.
2025-08-01
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| Series: | Frontiers in Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2025.1574896/full |
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| author | Jiefeng Jiang Jiefeng Jiang Lyuxin Guan Ziqin Gan Zhili Wu Zhili Wu Xiaofeng Liang Xiaofeng Liang Zhiwen Zhang Zhiwen Zhang Yansi Lyu Yunsheng Liang |
| author_facet | Jiefeng Jiang Jiefeng Jiang Lyuxin Guan Ziqin Gan Zhili Wu Zhili Wu Xiaofeng Liang Xiaofeng Liang Zhiwen Zhang Zhiwen Zhang Yansi Lyu Yunsheng Liang |
| author_sort | Jiefeng Jiang |
| collection | DOAJ |
| description | BackgroundPsoriatic arthritis (PsA) has been closely associated with an elevated risk of cardiovascular disease (CVD). Nevertheless, the connection between Life’s Crucial 9 (LC9), which serves as a holistic measure of cardiovascular health (CVH), and PsA remains insufficiently studied. This research aims to explore the potential relationship between LC9 and the prevalence of PsA.ObjectiveTo investigate the role of LC9 in PsA and explore its implications.MethodsThis study utilized a cross-sectional, population-based design, analyzing data from 7,531 U.S. participants aged 20 years or older, drawn from the 2005–2006 and 2009–2014 cycles of the National Health and Nutrition Examination Survey (NHANES). The LC9 score, which encompasses nine distinct components, was classified into three CVH categories: low, moderate, and high. To explore the association between LC9 scores and the prevalence of PsA, logistic regression models and restricted cubic splines were applied.ResultsIn the analyzed cohort of 7,531 individuals, participants with moderate or high CVH levels demonstrated a markedly reduced likelihood of developing PsA relative to those with low CVH. Additionally, a 10-point elevation in the LC9 score was associated with a 32% lower odds of having PsA. A notable interaction between LC9 and age was detected. Conversely, no meaningful link was found between LC9 and psoriasis without arthritis (PsC).ConclusionThe LC9 score and its subcomponents are significantly negatively correlated with the risk of PsA. This suggests that adherence to the lifestyle defined by LC9 is associated with a lower prevalence of PsA. |
| format | Article |
| id | doaj-art-65d9cfc72d78443a907f17703c38edfd |
| institution | DOAJ |
| issn | 2296-858X |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj-art-65d9cfc72d78443a907f17703c38edfd2025-08-20T02:57:30ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2025-08-011210.3389/fmed.2025.15748961574896Association between Life’s Crucial 9 and psoriatic arthritis in U.S. adults: a cross-sectional studyJiefeng Jiang0Jiefeng Jiang1Lyuxin Guan2Ziqin Gan3Zhili Wu4Zhili Wu5Xiaofeng Liang6Xiaofeng Liang7Zhiwen Zhang8Zhiwen Zhang9Yansi Lyu10Yunsheng Liang11The First School of Clinical Medicine, Southern Medical University, Guangzhou, ChinaDermatology Hospital, Southern Medical University, Guangzhou, ChinaDepartment of Burn and Plastic Surgery, The First Affiliated Hospital of Shenzhen University, Shenzhen, ChinaDepartment of Dermatology, The Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai, ChinaThe First School of Clinical Medicine, Southern Medical University, Guangzhou, ChinaDermatology Hospital, Southern Medical University, Guangzhou, ChinaThe First School of Clinical Medicine, Southern Medical University, Guangzhou, ChinaDermatology Hospital, Southern Medical University, Guangzhou, ChinaThe First School of Clinical Medicine, Southern Medical University, Guangzhou, ChinaDermatology Hospital, Southern Medical University, Guangzhou, ChinaDepartment of Dermatology, Shenzhen University General Hospital, Shenzhen, ChinaDermatology Hospital, Southern Medical University, Guangzhou, ChinaBackgroundPsoriatic arthritis (PsA) has been closely associated with an elevated risk of cardiovascular disease (CVD). Nevertheless, the connection between Life’s Crucial 9 (LC9), which serves as a holistic measure of cardiovascular health (CVH), and PsA remains insufficiently studied. This research aims to explore the potential relationship between LC9 and the prevalence of PsA.ObjectiveTo investigate the role of LC9 in PsA and explore its implications.MethodsThis study utilized a cross-sectional, population-based design, analyzing data from 7,531 U.S. participants aged 20 years or older, drawn from the 2005–2006 and 2009–2014 cycles of the National Health and Nutrition Examination Survey (NHANES). The LC9 score, which encompasses nine distinct components, was classified into three CVH categories: low, moderate, and high. To explore the association between LC9 scores and the prevalence of PsA, logistic regression models and restricted cubic splines were applied.ResultsIn the analyzed cohort of 7,531 individuals, participants with moderate or high CVH levels demonstrated a markedly reduced likelihood of developing PsA relative to those with low CVH. Additionally, a 10-point elevation in the LC9 score was associated with a 32% lower odds of having PsA. A notable interaction between LC9 and age was detected. Conversely, no meaningful link was found between LC9 and psoriasis without arthritis (PsC).ConclusionThe LC9 score and its subcomponents are significantly negatively correlated with the risk of PsA. This suggests that adherence to the lifestyle defined by LC9 is associated with a lower prevalence of PsA.https://www.frontiersin.org/articles/10.3389/fmed.2025.1574896/fullcardiovascular healthLife’s Crucial 9NHANESpsoriasispsoriatic arthritis |
| spellingShingle | Jiefeng Jiang Jiefeng Jiang Lyuxin Guan Ziqin Gan Zhili Wu Zhili Wu Xiaofeng Liang Xiaofeng Liang Zhiwen Zhang Zhiwen Zhang Yansi Lyu Yunsheng Liang Association between Life’s Crucial 9 and psoriatic arthritis in U.S. adults: a cross-sectional study Frontiers in Medicine cardiovascular health Life’s Crucial 9 NHANES psoriasis psoriatic arthritis |
| title | Association between Life’s Crucial 9 and psoriatic arthritis in U.S. adults: a cross-sectional study |
| title_full | Association between Life’s Crucial 9 and psoriatic arthritis in U.S. adults: a cross-sectional study |
| title_fullStr | Association between Life’s Crucial 9 and psoriatic arthritis in U.S. adults: a cross-sectional study |
| title_full_unstemmed | Association between Life’s Crucial 9 and psoriatic arthritis in U.S. adults: a cross-sectional study |
| title_short | Association between Life’s Crucial 9 and psoriatic arthritis in U.S. adults: a cross-sectional study |
| title_sort | association between life s crucial 9 and psoriatic arthritis in u s adults a cross sectional study |
| topic | cardiovascular health Life’s Crucial 9 NHANES psoriasis psoriatic arthritis |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2025.1574896/full |
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