CXCL12/CXCR4 axis governs Treg spatial dominance over CD8+ T cells via IL-2 sequestration: a dual therapeutic target in prostate cancer

CXCL12/CXCR4 axis governs Treg spatial dominance over CD8+ T cells via IL-2 sequestration: a dual therapeutic target in prostate cancer

BackgroundProstate cancer (PCa) is characterized by high incidence and recurrence rates, presenting as an immune ‘cold’ tumor that exhibits a poor response to immunotherapy. The mechanisms underlying immune suppression and evasion within the tumor microenvironment (TME) of PCa remain inadequately un...

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Bibliographic Details
Main Authors: Junyi Li, Long Zhang, Ruoyang Liu, Changwen Xu, HuiHui Tang, Yunfei Zou, Qingfei Cao, Weichao Huang
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Immunology
Subjects:
prostate cancer
tumor immune microenvironment
CD8+ T cell
regulatory T cells
CXCL12/CXCR4 axis
IL-2/STAT5 signaling
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1626708/full
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