Lactobacillus johnsonii alleviates experimental colitis by restoring intestinal barrier function and reducing NET-mediated gut-liver inflammation

Abstract Inflammatory bowel disease (IBD) remains a global health challenge linked to intestinal barrier disruption, microbiota dysbiosis, and immune dysregulation, though the interplay of these mechanisms remains poorly defined. Here, we investigated the therapeutic potential of Lactobacillus johns...

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Main Authors: Hao-Yu Liu, Peng Yuan, Shicheng Li, Kennedy Jerry Ogamune, Xinyu Shi, Cuipeng Zhu, Wael Ennab, Ping Hu, Abdelkareem A. Ahmed, Yunzeng Zhang, In Ho Kim, Demin Cai
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-025-08679-4
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