Molecular Mechanisms by Which Imeglimin Improves Glucose Homeostasis
Despite different classes of antidiabetic medications available for the management of patients with diabetes, efforts are underway to identify novel and safer antihyperglycemic agents with higher potency and increased tolerability. Imeglimin is a promising antidiabetic agent that has shown to have s...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2020-01-01
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| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2020/8768954 |
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| _version_ | 1850158627385507840 |
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| author | Habib Yaribeygi Mina Maleki Thozhukat Sathyapalan Tannaz Jamialahmadi Amirhossein Sahebkar |
| author_facet | Habib Yaribeygi Mina Maleki Thozhukat Sathyapalan Tannaz Jamialahmadi Amirhossein Sahebkar |
| author_sort | Habib Yaribeygi |
| collection | DOAJ |
| description | Despite different classes of antidiabetic medications available for the management of patients with diabetes, efforts are underway to identify novel and safer antihyperglycemic agents with higher potency and increased tolerability. Imeglimin is a promising antidiabetic agent that has shown to have significant antihyperglycemic effects in studies, although it has not been approved yet. There is growing evidence that imeglimin improves glucose homeostasis in the diabetic milieu; however, the precise molecular mechanisms are still not elucidated. In this review, we discuss various molecular pathways by which imeglimin exerts its antihyperglycemic effects and improves glucose homeostasis in the diabetic milieu. |
| format | Article |
| id | doaj-art-65d38b4ebde246bbadac5a59a724f460 |
| institution | OA Journals |
| issn | 2314-6745 2314-6753 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-65d38b4ebde246bbadac5a59a724f4602025-08-20T02:23:49ZengWileyJournal of Diabetes Research2314-67452314-67532020-01-01202010.1155/2020/87689548768954Molecular Mechanisms by Which Imeglimin Improves Glucose HomeostasisHabib Yaribeygi0Mina Maleki1Thozhukat Sathyapalan2Tannaz Jamialahmadi3Amirhossein Sahebkar4Research Center of Physiology, Semnan University of Medical Sciences, Semnan, IranChronic Kidney Disease Research Center, Shahid Beheshti University of Medical Sciences, Tehran, IranAcademic Diabetes, Endocrinology and Metabolism, Hull York Medical School, University of Hull, Tehran, IranBiotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, IranHalal Research Center of IRI, FDA, Tehran, IranDespite different classes of antidiabetic medications available for the management of patients with diabetes, efforts are underway to identify novel and safer antihyperglycemic agents with higher potency and increased tolerability. Imeglimin is a promising antidiabetic agent that has shown to have significant antihyperglycemic effects in studies, although it has not been approved yet. There is growing evidence that imeglimin improves glucose homeostasis in the diabetic milieu; however, the precise molecular mechanisms are still not elucidated. In this review, we discuss various molecular pathways by which imeglimin exerts its antihyperglycemic effects and improves glucose homeostasis in the diabetic milieu.http://dx.doi.org/10.1155/2020/8768954 |
| spellingShingle | Habib Yaribeygi Mina Maleki Thozhukat Sathyapalan Tannaz Jamialahmadi Amirhossein Sahebkar Molecular Mechanisms by Which Imeglimin Improves Glucose Homeostasis Journal of Diabetes Research |
| title | Molecular Mechanisms by Which Imeglimin Improves Glucose Homeostasis |
| title_full | Molecular Mechanisms by Which Imeglimin Improves Glucose Homeostasis |
| title_fullStr | Molecular Mechanisms by Which Imeglimin Improves Glucose Homeostasis |
| title_full_unstemmed | Molecular Mechanisms by Which Imeglimin Improves Glucose Homeostasis |
| title_short | Molecular Mechanisms by Which Imeglimin Improves Glucose Homeostasis |
| title_sort | molecular mechanisms by which imeglimin improves glucose homeostasis |
| url | http://dx.doi.org/10.1155/2020/8768954 |
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