Effect of Bacterial Nanocellulose with Chemisorbed Antiseptics on Alveolar Bone Repair in Rats Undergoing Bisphosphonate Therapy
<b>Objectives</b>: This work investigated the effect of bacterial nanocellulose (BNC) alone or with chemisorbed chlorhexidine or povidone-iodine on post-tooth extraction repair in rats undergoing bisphosphonate therapy. <b>Methods</b>: Forty Wistar rats were treated with zole...
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2024-12-01
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| Online Access: | https://www.mdpi.com/1999-4923/17/1/24 |
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| author | Marcelo Matos Rocha Valesca Sander Koth Marcela Wiltgen Jeffman Fernanda Gonçalves Salum Josiane de Almeida Karina Cesca Karen Cherubini |
| author_facet | Marcelo Matos Rocha Valesca Sander Koth Marcela Wiltgen Jeffman Fernanda Gonçalves Salum Josiane de Almeida Karina Cesca Karen Cherubini |
| author_sort | Marcelo Matos Rocha |
| collection | DOAJ |
| description | <b>Objectives</b>: This work investigated the effect of bacterial nanocellulose (BNC) alone or with chemisorbed chlorhexidine or povidone-iodine on post-tooth extraction repair in rats undergoing bisphosphonate therapy. <b>Methods</b>: Forty Wistar rats were treated with zoledronic acid, subjected to tooth extractions and allocated into groups according to the material inserted in the post-extraction socket: (1) BNC (<i>n</i> = 10); (2) BNC/Iodine (<i>n</i> = 10); (3) BNC/Chlorhex (<i>n</i> = 10); (4) Control (<i>n</i> = 10). Maxillae were dissected and macro- and microscopically analyzed. <b>Results</b>: Oral lesion frequency on macroscopic examination did not differ between the groups, whereas it was larger in the BNC/Iodine group compared to the BNC/Chlorhex and Control. BNC/Chlorhex had significantly more connective tissue than did BNC but did not differ from the BNC/Iodine and Control. Epithelium, vital bone, non-vital bone, tooth fragment and inflammatory infiltrate did not significantly differ between the groups. BNC/Iodine showed greater CD31 immunostaining compared to BNC and the Control. Myeloperoxidase staining did not differ between the groups, and scanning electron microscopy analysis showed similar characteristics in all groups. <b>Conclusions</b>: BNC with chemisorbed povidone-iodine is associated with increased vascularization in post-extraction wounds of rats undergoing bisphosphonate therapy, whereas BNC with chemisorbed chlorhexidine improves connective tissue formation. BNC works as an effective carrier for the antiseptics tested. |
| format | Article |
| id | doaj-art-65c8a12aba384617b3cf428cd2d6ec72 |
| institution | Kabale University |
| issn | 1999-4923 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj-art-65c8a12aba384617b3cf428cd2d6ec722025-01-24T13:45:37ZengMDPI AGPharmaceutics1999-49232024-12-011712410.3390/pharmaceutics17010024Effect of Bacterial Nanocellulose with Chemisorbed Antiseptics on Alveolar Bone Repair in Rats Undergoing Bisphosphonate TherapyMarcelo Matos Rocha0Valesca Sander Koth1Marcela Wiltgen Jeffman2Fernanda Gonçalves Salum3Josiane de Almeida4Karina Cesca5Karen Cherubini6Post-Graduate Program in Dentistry, School of Health and Life Sciences, Pontifical Catholic University of Rio Grande do Sul (PUCRS), Porto Alegre 90619-900, RS, BrazilPost-Graduate Program in Dentistry, School of Health and Life Sciences, Pontifical Catholic University of Rio Grande do Sul (PUCRS), Porto Alegre 90619-900, RS, BrazilPost-Graduate Program in Dentistry, School of Health and Life Sciences, Pontifical Catholic University of Rio Grande do Sul (PUCRS), Porto Alegre 90619-900, RS, BrazilPost-Graduate Program in Dentistry, School of Health and Life Sciences, Pontifical Catholic University of Rio Grande do Sul (PUCRS), Porto Alegre 90619-900, RS, BrazilDepartment of Endodontics, University of Southern Santa Catarina (UNISUL), Tubarão 88704-900, SC, BrazilDepartment of Chemical Engineering and Food Engineering, Federal University of Santa Catarina (UFSC), Florianópolis 88040–900, SC, BrazilPost-Graduate Program in Dentistry, School of Health and Life Sciences, Pontifical Catholic University of Rio Grande do Sul (PUCRS), Porto Alegre 90619-900, RS, Brazil<b>Objectives</b>: This work investigated the effect of bacterial nanocellulose (BNC) alone or with chemisorbed chlorhexidine or povidone-iodine on post-tooth extraction repair in rats undergoing bisphosphonate therapy. <b>Methods</b>: Forty Wistar rats were treated with zoledronic acid, subjected to tooth extractions and allocated into groups according to the material inserted in the post-extraction socket: (1) BNC (<i>n</i> = 10); (2) BNC/Iodine (<i>n</i> = 10); (3) BNC/Chlorhex (<i>n</i> = 10); (4) Control (<i>n</i> = 10). Maxillae were dissected and macro- and microscopically analyzed. <b>Results</b>: Oral lesion frequency on macroscopic examination did not differ between the groups, whereas it was larger in the BNC/Iodine group compared to the BNC/Chlorhex and Control. BNC/Chlorhex had significantly more connective tissue than did BNC but did not differ from the BNC/Iodine and Control. Epithelium, vital bone, non-vital bone, tooth fragment and inflammatory infiltrate did not significantly differ between the groups. BNC/Iodine showed greater CD31 immunostaining compared to BNC and the Control. Myeloperoxidase staining did not differ between the groups, and scanning electron microscopy analysis showed similar characteristics in all groups. <b>Conclusions</b>: BNC with chemisorbed povidone-iodine is associated with increased vascularization in post-extraction wounds of rats undergoing bisphosphonate therapy, whereas BNC with chemisorbed chlorhexidine improves connective tissue formation. BNC works as an effective carrier for the antiseptics tested.https://www.mdpi.com/1999-4923/17/1/24bacterial cellulosenanocellulosebone tissue regenerationgraft |
| spellingShingle | Marcelo Matos Rocha Valesca Sander Koth Marcela Wiltgen Jeffman Fernanda Gonçalves Salum Josiane de Almeida Karina Cesca Karen Cherubini Effect of Bacterial Nanocellulose with Chemisorbed Antiseptics on Alveolar Bone Repair in Rats Undergoing Bisphosphonate Therapy Pharmaceutics bacterial cellulose nanocellulose bone tissue regeneration graft |
| title | Effect of Bacterial Nanocellulose with Chemisorbed Antiseptics on Alveolar Bone Repair in Rats Undergoing Bisphosphonate Therapy |
| title_full | Effect of Bacterial Nanocellulose with Chemisorbed Antiseptics on Alveolar Bone Repair in Rats Undergoing Bisphosphonate Therapy |
| title_fullStr | Effect of Bacterial Nanocellulose with Chemisorbed Antiseptics on Alveolar Bone Repair in Rats Undergoing Bisphosphonate Therapy |
| title_full_unstemmed | Effect of Bacterial Nanocellulose with Chemisorbed Antiseptics on Alveolar Bone Repair in Rats Undergoing Bisphosphonate Therapy |
| title_short | Effect of Bacterial Nanocellulose with Chemisorbed Antiseptics on Alveolar Bone Repair in Rats Undergoing Bisphosphonate Therapy |
| title_sort | effect of bacterial nanocellulose with chemisorbed antiseptics on alveolar bone repair in rats undergoing bisphosphonate therapy |
| topic | bacterial cellulose nanocellulose bone tissue regeneration graft |
| url | https://www.mdpi.com/1999-4923/17/1/24 |
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