Characterization of the growth-inhibitory and apoptosis-inducing activities of a triterpene saponin, securioside B against BAC1.2F5 macrophages
Background: Since the growth state of macrophages in local pathological sites is considered a factor that regulates the processes of many disease, such as tumors, inflammation, and atherosclerosis, the substances that regulate macrophage growth or survival may be useful for disease control. We previ...
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| Format: | Article |
| Language: | English |
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Wiley
2003-01-01
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| Series: | Mediators of Inflammation |
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| Online Access: | http://dx.doi.org/10.1080/0962935031000134879 |
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| author | Satoru Yui Tomoya Kudo Kazumi Hodono Yoshihiro Mimaki Minpei Kuroda Yutaka Sashida Masatoshi Yamazaki |
| author_facet | Satoru Yui Tomoya Kudo Kazumi Hodono Yoshihiro Mimaki Minpei Kuroda Yutaka Sashida Masatoshi Yamazaki |
| author_sort | Satoru Yui |
| collection | DOAJ |
| description | Background: Since the growth state of macrophages in local pathological sites is considered a factor that regulates the processes of many disease, such as tumors, inflammation, and atherosclerosis, the substances that regulate macrophage growth or survival may be useful for disease control. We previously reported that securiosides A and B, novel triterpene saponins, exerted macrophage-oriented cytotoxicity in the presence of a L-cell-conditioned medium containing macrophage colony-stimulating factor (M-CSF), while the compounds did not exhibit an effect on macrophages in the absence of the growth-stimulating factors. |
| format | Article |
| id | doaj-art-65c4602e753c41aa808c3b0453eb041e |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2003-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-65c4602e753c41aa808c3b0453eb041e2025-02-03T01:09:32ZengWileyMediators of Inflammation0962-93511466-18612003-01-0112315716610.1080/0962935031000134879Characterization of the growth-inhibitory and apoptosis-inducing activities of a triterpene saponin, securioside B against BAC1.2F5 macrophagesSatoru Yui0Tomoya Kudo1Kazumi Hodono2Yoshihiro Mimaki3Minpei Kuroda4Yutaka Sashida5Masatoshi Yamazaki6Faculty of Pharmaceutical Sciences, Teikyo University, 1091-1 Sagamiko, Tsukui-gun, Kanagawa, 199-0195, JapanFaculty of Pharmaceutical Sciences, Teikyo University, 1091-1 Sagamiko, Tsukui-gun, Kanagawa, 199-0195, JapanFaculty of Pharmaceutical Sciences, Teikyo University, 1091-1 Sagamiko, Tsukui-gun, Kanagawa, 199-0195, JapanLaboratory of Medicinal Plant Science, School of Pharmacy, Tokyo University of Pharmacy and Life Science, Horinouchi, Hachioji, Tokyo, JapanLaboratory of Medicinal Plant Science, School of Pharmacy, Tokyo University of Pharmacy and Life Science, Horinouchi, Hachioji, Tokyo, JapanLaboratory of Medicinal Plant Science, School of Pharmacy, Tokyo University of Pharmacy and Life Science, Horinouchi, Hachioji, Tokyo, JapanFaculty of Pharmaceutical Sciences, Teikyo University, 1091-1 Sagamiko, Tsukui-gun, Kanagawa, 199-0195, JapanBackground: Since the growth state of macrophages in local pathological sites is considered a factor that regulates the processes of many disease, such as tumors, inflammation, and atherosclerosis, the substances that regulate macrophage growth or survival may be useful for disease control. We previously reported that securiosides A and B, novel triterpene saponins, exerted macrophage-oriented cytotoxicity in the presence of a L-cell-conditioned medium containing macrophage colony-stimulating factor (M-CSF), while the compounds did not exhibit an effect on macrophages in the absence of the growth-stimulating factors.http://dx.doi.org/10.1080/0962935031000134879MacrophagesGrowth inhibitionApoptosisSecurioside BBAC1.2F5 cellsL-cell-conditioned mediumM-CSFGM-CSF. |
| spellingShingle | Satoru Yui Tomoya Kudo Kazumi Hodono Yoshihiro Mimaki Minpei Kuroda Yutaka Sashida Masatoshi Yamazaki Characterization of the growth-inhibitory and apoptosis-inducing activities of a triterpene saponin, securioside B against BAC1.2F5 macrophages Mediators of Inflammation Macrophages Growth inhibition Apoptosis Securioside B BAC1.2F5 cells L-cell-conditioned medium M-CSF GM-CSF. |
| title | Characterization of the growth-inhibitory and apoptosis-inducing activities of a triterpene saponin, securioside B against BAC1.2F5 macrophages |
| title_full | Characterization of the growth-inhibitory and apoptosis-inducing activities of a triterpene saponin, securioside B against BAC1.2F5 macrophages |
| title_fullStr | Characterization of the growth-inhibitory and apoptosis-inducing activities of a triterpene saponin, securioside B against BAC1.2F5 macrophages |
| title_full_unstemmed | Characterization of the growth-inhibitory and apoptosis-inducing activities of a triterpene saponin, securioside B against BAC1.2F5 macrophages |
| title_short | Characterization of the growth-inhibitory and apoptosis-inducing activities of a triterpene saponin, securioside B against BAC1.2F5 macrophages |
| title_sort | characterization of the growth inhibitory and apoptosis inducing activities of a triterpene saponin securioside b against bac1 2f5 macrophages |
| topic | Macrophages Growth inhibition Apoptosis Securioside B BAC1.2F5 cells L-cell-conditioned medium M-CSF GM-CSF. |
| url | http://dx.doi.org/10.1080/0962935031000134879 |
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