The identification of functional regions of MEK1 using CRISPR tiling screens

The identification of functional regions of MEK1 using CRISPR tiling screens

Abstract CRISPR tiling screen is a powerful tool to identify protein regions relevant to its biological function. Understanding the functional relevance of the regions of target protein is of great help for structure-based drug discovery. Studying the drug resistance mechanisms of small-molecule inh...

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Bibliographic Details
Main Authors: Zhiqiang Zhang, Barbara Abreu, Jessica L. Brothwood, John Alexander, Martin J. Sims, John F. Lyons, Joanne M. Munck, Christopher J. Hindley
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-025-07966-4
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