Investigating the Role of Genetic Polymorphisms in External Apical Root Resorption Among Orthodontic Patients: Implications for Treatment Outcomes—A Literature Review
<b>Background:</b> Among the various forms of root resorption, External Apical Root Resorption (EARR) has garnered particular attention due to its prevalence and potential complications associated with orthodontic interventions. <b>Methods:</b> An electronic search of literat...
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2025-01-01
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| author | Christina Charisi Vasileios Zisis Konstantinos Poulopoulos Stefanos Zisis Athanasios Poulopoulos Dieter Müßig |
| author_facet | Christina Charisi Vasileios Zisis Konstantinos Poulopoulos Stefanos Zisis Athanasios Poulopoulos Dieter Müßig |
| author_sort | Christina Charisi |
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| description | <b>Background:</b> Among the various forms of root resorption, External Apical Root Resorption (EARR) has garnered particular attention due to its prevalence and potential complications associated with orthodontic interventions. <b>Methods:</b> An electronic search of literature was performed between September 2024 and December 2024 to identify all articles investigating the Role of Genetic Polymorphisms in External Apical Root Resorption Among Orthodontic Patients: Implications for Treatment Outcomes. The search was conducted using MEDLINE (National Library of Medicine)-PubMed with restrictions concerning the date of publication. In particular, we focused on the period 2014–2024 using the following keywords: gene polymorphisms AND orthodontic treatment AND apical root resorption OR external apical root resorption. This was followed by a manual search, and references were used to identify relevant articles. <b>Results:</b> The review showed that certain variations of the following genes may be positively associated with OIEARR: Osteopontin gene, P2RX7, IL-1β, IL-6, IL1RN, OPG, RANK, STAG2, RP1-30E17.2, SSP1, SFRP2, TNFSF11, TNFRSF11A, TNFRSF11B, VDR, CYP27B1, ACT3N, TSC2, WNT3A, LRP1, LRP6. Conversely, the IRAK1 gene has a protective function against the development of OIEARR. <b>Conclusions:</b> Despite these advancements, it is still not feasible to establish new guidelines and clinical protocols based on the existing research findings. The integration of genetic considerations into orthodontic practice has the potential to revolutionize treatment strategies, ensuring that they are not only effective but also respectful of each patient’s unique biological landscape. |
| format | Article |
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| language | English |
| publishDate | 2025-01-01 |
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| spelling | doaj-art-65bbecedcea841e59b283d7525972d892025-08-20T02:43:06ZengMDPI AGReports2571-841X2025-01-01811410.3390/reports8010014Investigating the Role of Genetic Polymorphisms in External Apical Root Resorption Among Orthodontic Patients: Implications for Treatment Outcomes—A Literature ReviewChristina Charisi0Vasileios Zisis1Konstantinos Poulopoulos2Stefanos Zisis3Athanasios Poulopoulos4Dieter Müßig5Department of Orthodontics, School of Dentistry, Danube Private University, 3500 Krems, AustriaDepartment of Oral Medicine and Pathology, School of Dentistry, Aristotle University of Thessaloniki, 54124 Thessaloniki, GreeceDepartment of Oral Medicine and Pathology, School of Dentistry, Aristotle University of Thessaloniki, 54124 Thessaloniki, GreeceDepartment of Periodontology, School of Dentistry, Aachen University, 52074 Aachen, GermanyDepartment of Oral Medicine and Pathology, School of Dentistry, Aristotle University of Thessaloniki, 54124 Thessaloniki, GreeceDepartment of Orthodontics, School of Dentistry, Danube Private University, 3500 Krems, Austria<b>Background:</b> Among the various forms of root resorption, External Apical Root Resorption (EARR) has garnered particular attention due to its prevalence and potential complications associated with orthodontic interventions. <b>Methods:</b> An electronic search of literature was performed between September 2024 and December 2024 to identify all articles investigating the Role of Genetic Polymorphisms in External Apical Root Resorption Among Orthodontic Patients: Implications for Treatment Outcomes. The search was conducted using MEDLINE (National Library of Medicine)-PubMed with restrictions concerning the date of publication. In particular, we focused on the period 2014–2024 using the following keywords: gene polymorphisms AND orthodontic treatment AND apical root resorption OR external apical root resorption. This was followed by a manual search, and references were used to identify relevant articles. <b>Results:</b> The review showed that certain variations of the following genes may be positively associated with OIEARR: Osteopontin gene, P2RX7, IL-1β, IL-6, IL1RN, OPG, RANK, STAG2, RP1-30E17.2, SSP1, SFRP2, TNFSF11, TNFRSF11A, TNFRSF11B, VDR, CYP27B1, ACT3N, TSC2, WNT3A, LRP1, LRP6. Conversely, the IRAK1 gene has a protective function against the development of OIEARR. <b>Conclusions:</b> Despite these advancements, it is still not feasible to establish new guidelines and clinical protocols based on the existing research findings. The integration of genetic considerations into orthodontic practice has the potential to revolutionize treatment strategies, ensuring that they are not only effective but also respectful of each patient’s unique biological landscape.https://www.mdpi.com/2571-841X/8/1/14root resorptionapicalexternalorthodontically inducedorthodontic treatmentgene polymorphisms |
| spellingShingle | Christina Charisi Vasileios Zisis Konstantinos Poulopoulos Stefanos Zisis Athanasios Poulopoulos Dieter Müßig Investigating the Role of Genetic Polymorphisms in External Apical Root Resorption Among Orthodontic Patients: Implications for Treatment Outcomes—A Literature Review Reports root resorption apical external orthodontically induced orthodontic treatment gene polymorphisms |
| title | Investigating the Role of Genetic Polymorphisms in External Apical Root Resorption Among Orthodontic Patients: Implications for Treatment Outcomes—A Literature Review |
| title_full | Investigating the Role of Genetic Polymorphisms in External Apical Root Resorption Among Orthodontic Patients: Implications for Treatment Outcomes—A Literature Review |
| title_fullStr | Investigating the Role of Genetic Polymorphisms in External Apical Root Resorption Among Orthodontic Patients: Implications for Treatment Outcomes—A Literature Review |
| title_full_unstemmed | Investigating the Role of Genetic Polymorphisms in External Apical Root Resorption Among Orthodontic Patients: Implications for Treatment Outcomes—A Literature Review |
| title_short | Investigating the Role of Genetic Polymorphisms in External Apical Root Resorption Among Orthodontic Patients: Implications for Treatment Outcomes—A Literature Review |
| title_sort | investigating the role of genetic polymorphisms in external apical root resorption among orthodontic patients implications for treatment outcomes a literature review |
| topic | root resorption apical external orthodontically induced orthodontic treatment gene polymorphisms |
| url | https://www.mdpi.com/2571-841X/8/1/14 |
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