Decrease in phase angle after Roux-en-Y gastric bypass is related to increase of anti-inflammatory status
Summary: Background & Aims: Phase angle (PhA) has been used as a prognostic indicator in various clinical conditions. However, its relationship with inflammatory state during obesity treatment is less known. This study investigated the relationship between PhA and inflammatory parameters in...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-02-01
|
| Series: | Clinical Nutrition Open Science |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2667268525000026 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832590885328519168 |
|---|---|
| author | Amanda Cristina Araújo Gomes Amanda Machado Fiorotti Amanda Motta de Bortoli Beatriz Bobbio de Brito João Arthur Souza Fiorido Luciane Bresciani Salaroli Andressa Bolsoni Lopes Fabiano Kenji Haraguchi |
| author_facet | Amanda Cristina Araújo Gomes Amanda Machado Fiorotti Amanda Motta de Bortoli Beatriz Bobbio de Brito João Arthur Souza Fiorido Luciane Bresciani Salaroli Andressa Bolsoni Lopes Fabiano Kenji Haraguchi |
| author_sort | Amanda Cristina Araújo Gomes |
| collection | DOAJ |
| description | Summary: Background & Aims: Phase angle (PhA) has been used as a prognostic indicator in various clinical conditions. However, its relationship with inflammatory state during obesity treatment is less known. This study investigated the relationship between PhA and inflammatory parameters in patients undergoing Roux-en-Y gastric bypass (RYGB). Methods: This is a prospective longitudinal study with patients from the Bariatric and Metabolic Surgery Program of a university hospital. Analyses were conducted pre-RYGB and about two and six months post-RYGB. Assessments included serum levels of alpha-1-acid glycoprotein (AGP), C-reactive protein (CRP), tumor necrosis factor-alpha (TNF-α), adiponectin, and resistin, as well as anthropometric data and body composition. Data were analyzed using the one-way repeated measures ANOVA or Friedman's test, followed by Tukey's post hoc test. Relationship between PhA and biochemical and body parameters were assessed using the Spearman or Pearson correlation coefficient. A significance level of 5% was adopted. Results: Final sample was composed of 23 subjects (87% women), aged 40.6 ± 10.7 years. A significant decrease in PhA values accompanied by an improvement in inflammatory parameters were observed post-RYGB (p<0.05). PhA values was inversely correlated with serum adiponectin concentrations (r= −0.376, p<0.05). In addition, BMI and fat-mass were also significantly correlated with serum adiponectin (r= −0.264 for BMI and r= −0.277 for fat-mass, p<0.05) and TNF-alpha (r= 0.338 for BMI and r= 0.335 for fat-mass, p<0.05), whereas serum resistin was correlated only with fat-mass (r= 0.245, p<0.05). Conclusions: Data suggest that the decrease in PhA values during six months post-RYGB may indicate a concomitant improvement of anti-inflammatory state. |
| format | Article |
| id | doaj-art-65bb00e7e77e4f7196f698d18189b814 |
| institution | Kabale University |
| issn | 2667-2685 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Clinical Nutrition Open Science |
| spelling | doaj-art-65bb00e7e77e4f7196f698d18189b8142025-01-23T05:27:55ZengElsevierClinical Nutrition Open Science2667-26852025-02-0159159170Decrease in phase angle after Roux-en-Y gastric bypass is related to increase of anti-inflammatory statusAmanda Cristina Araújo Gomes0Amanda Machado Fiorotti1Amanda Motta de Bortoli2Beatriz Bobbio de Brito3João Arthur Souza Fiorido4Luciane Bresciani Salaroli5Andressa Bolsoni Lopes6Fabiano Kenji Haraguchi7Postgraduate Program in Nutrition and Health, Health Sciences Center, Federal University of Espírito Santo, Av. Mal. Campos, 1468 - Maruípe, Vitória, ES, 29047-100, BrazilPostgraduate Program in Nutrition and Health, Health Sciences Center, Federal University of Espírito Santo, Av. Mal. Campos, 1468 - Maruípe, Vitória, ES, 29047-100, BrazilPostgraduate Program in Nutrition and Health, Health Sciences Center, Federal University of Espírito Santo, Av. Mal. Campos, 1468 - Maruípe, Vitória, ES, 29047-100, BrazilPostgraduate Program in Nutrition and Health, Health Sciences Center, Federal University of Espírito Santo, Av. Mal. Campos, 1468 - Maruípe, Vitória, ES, 29047-100, BrazilDepartment of Integrated Health Education, Health Sciences Center, Federal University of Espírito Santo, Av. Maruípe, 1386 - Maruípe, Vitória, ES, 29047-185, BrazilPostgraduate Program in Nutrition and Health, Health Sciences Center, Federal University of Espírito Santo, Av. Mal. Campos, 1468 - Maruípe, Vitória, ES, 29047-100, Brazil; Department of Integrated Health Education, Health Sciences Center, Federal University of Espírito Santo, Av. Maruípe, 1386 - Maruípe, Vitória, ES, 29047-185, BrazilPostgraduate Program in Nutrition and Health, Health Sciences Center, Federal University of Espírito Santo, Av. Mal. Campos, 1468 - Maruípe, Vitória, ES, 29047-100, BrazilPostgraduate Program in Nutrition and Health, Health Sciences Center, Federal University of Espírito Santo, Av. Mal. Campos, 1468 - Maruípe, Vitória, ES, 29047-100, Brazil; Department of Integrated Health Education, Health Sciences Center, Federal University of Espírito Santo, Av. Maruípe, 1386 - Maruípe, Vitória, ES, 29047-185, Brazil; Corresponding author. Postgraduate Program in Nutrition and Health, Health Sciences Center, Federal University of Espírito Santo, Vitória, ES, CEP: 29040-090, Brazil.Summary: Background & Aims: Phase angle (PhA) has been used as a prognostic indicator in various clinical conditions. However, its relationship with inflammatory state during obesity treatment is less known. This study investigated the relationship between PhA and inflammatory parameters in patients undergoing Roux-en-Y gastric bypass (RYGB). Methods: This is a prospective longitudinal study with patients from the Bariatric and Metabolic Surgery Program of a university hospital. Analyses were conducted pre-RYGB and about two and six months post-RYGB. Assessments included serum levels of alpha-1-acid glycoprotein (AGP), C-reactive protein (CRP), tumor necrosis factor-alpha (TNF-α), adiponectin, and resistin, as well as anthropometric data and body composition. Data were analyzed using the one-way repeated measures ANOVA or Friedman's test, followed by Tukey's post hoc test. Relationship between PhA and biochemical and body parameters were assessed using the Spearman or Pearson correlation coefficient. A significance level of 5% was adopted. Results: Final sample was composed of 23 subjects (87% women), aged 40.6 ± 10.7 years. A significant decrease in PhA values accompanied by an improvement in inflammatory parameters were observed post-RYGB (p<0.05). PhA values was inversely correlated with serum adiponectin concentrations (r= −0.376, p<0.05). In addition, BMI and fat-mass were also significantly correlated with serum adiponectin (r= −0.264 for BMI and r= −0.277 for fat-mass, p<0.05) and TNF-alpha (r= 0.338 for BMI and r= 0.335 for fat-mass, p<0.05), whereas serum resistin was correlated only with fat-mass (r= 0.245, p<0.05). Conclusions: Data suggest that the decrease in PhA values during six months post-RYGB may indicate a concomitant improvement of anti-inflammatory state.http://www.sciencedirect.com/science/article/pii/S2667268525000026Bariatric surgeryPhase angleAdiponectinAnti-inflammatory profile |
| spellingShingle | Amanda Cristina Araújo Gomes Amanda Machado Fiorotti Amanda Motta de Bortoli Beatriz Bobbio de Brito João Arthur Souza Fiorido Luciane Bresciani Salaroli Andressa Bolsoni Lopes Fabiano Kenji Haraguchi Decrease in phase angle after Roux-en-Y gastric bypass is related to increase of anti-inflammatory status Clinical Nutrition Open Science Bariatric surgery Phase angle Adiponectin Anti-inflammatory profile |
| title | Decrease in phase angle after Roux-en-Y gastric bypass is related to increase of anti-inflammatory status |
| title_full | Decrease in phase angle after Roux-en-Y gastric bypass is related to increase of anti-inflammatory status |
| title_fullStr | Decrease in phase angle after Roux-en-Y gastric bypass is related to increase of anti-inflammatory status |
| title_full_unstemmed | Decrease in phase angle after Roux-en-Y gastric bypass is related to increase of anti-inflammatory status |
| title_short | Decrease in phase angle after Roux-en-Y gastric bypass is related to increase of anti-inflammatory status |
| title_sort | decrease in phase angle after roux en y gastric bypass is related to increase of anti inflammatory status |
| topic | Bariatric surgery Phase angle Adiponectin Anti-inflammatory profile |
| url | http://www.sciencedirect.com/science/article/pii/S2667268525000026 |
| work_keys_str_mv | AT amandacristinaaraujogomes decreaseinphaseangleafterrouxenygastricbypassisrelatedtoincreaseofantiinflammatorystatus AT amandamachadofiorotti decreaseinphaseangleafterrouxenygastricbypassisrelatedtoincreaseofantiinflammatorystatus AT amandamottadebortoli decreaseinphaseangleafterrouxenygastricbypassisrelatedtoincreaseofantiinflammatorystatus AT beatrizbobbiodebrito decreaseinphaseangleafterrouxenygastricbypassisrelatedtoincreaseofantiinflammatorystatus AT joaoarthursouzafiorido decreaseinphaseangleafterrouxenygastricbypassisrelatedtoincreaseofantiinflammatorystatus AT lucianebrescianisalaroli decreaseinphaseangleafterrouxenygastricbypassisrelatedtoincreaseofantiinflammatorystatus AT andressabolsonilopes decreaseinphaseangleafterrouxenygastricbypassisrelatedtoincreaseofantiinflammatorystatus AT fabianokenjiharaguchi decreaseinphaseangleafterrouxenygastricbypassisrelatedtoincreaseofantiinflammatorystatus |