Advanced Technologies for Large Scale Supply of Marine Drugs
Marine organisms represent a source of unique chemical entities with valuable biomedical potentialities, broad diversity, and complexity. It is essential to ensure a reliable and sustainable supply of marine natural products (MNPs) for their translation into commercial drugs and other valuable produ...
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| Format: | Article |
| Language: | English |
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MDPI AG
2025-02-01
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| Series: | Marine Drugs |
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| Online Access: | https://www.mdpi.com/1660-3397/23/2/69 |
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| author | Henar Martínez Mercedes Santos Lucía Pedraza Ana M. Testera |
| author_facet | Henar Martínez Mercedes Santos Lucía Pedraza Ana M. Testera |
| author_sort | Henar Martínez |
| collection | DOAJ |
| description | Marine organisms represent a source of unique chemical entities with valuable biomedical potentialities, broad diversity, and complexity. It is essential to ensure a reliable and sustainable supply of marine natural products (MNPs) for their translation into commercial drugs and other valuable products. From a structural point of view and with few exceptions, MNPs of pharmaceutical importance derive from the so-called secondary metabolism of marine organisms. When production strategies rely on marine macroorganisms, harvesting or culturing coupled with extraction procedures frequently remain the only alternative to producing these compounds on an industrial scale. Their supply can often be implemented with laboratory scale cultures for bacterial, fungal, or microalgal sources. However, a diverse approach, combining traditional methods with modern synthetic biology and biosynthesis strategies, must be considered for invertebrate MNPs, as they are usually naturally accumulated in only very small quantities. This review offers a comprehensive examination of various production strategies for MNPs, addressing the challenges related to supply, synthesis, and scalability. It also underscores recent biotechnological advancements that are likely to transform the current industrial-scale manufacturing methods for pharmaceuticals derived from marine sources. |
| format | Article |
| id | doaj-art-65af8ba4c449486182f6a54f201b5ddf |
| institution | OA Journals |
| issn | 1660-3397 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Marine Drugs |
| spelling | doaj-art-65af8ba4c449486182f6a54f201b5ddf2025-08-20T02:03:28ZengMDPI AGMarine Drugs1660-33972025-02-012326910.3390/md23020069Advanced Technologies for Large Scale Supply of Marine DrugsHenar Martínez0Mercedes Santos1Lucía Pedraza2Ana M. Testera3Department of Organic Chemistry, School of Engineering (EII), University of Valladolid (UVa), Dr. Mergelina, 47002 Valladolid, SpainDepartment of Organic Chemistry, School of Engineering (EII), University of Valladolid (UVa), Dr. Mergelina, 47002 Valladolid, SpainDepartment of Organic Chemistry, Science Faculty, University of Valladolid (UVa), Paseo de Belén 7, 47011 Valladolid, SpainDepartment of Organic Chemistry, School of Engineering (EII), University of Valladolid (UVa), Dr. Mergelina, 47002 Valladolid, SpainMarine organisms represent a source of unique chemical entities with valuable biomedical potentialities, broad diversity, and complexity. It is essential to ensure a reliable and sustainable supply of marine natural products (MNPs) for their translation into commercial drugs and other valuable products. From a structural point of view and with few exceptions, MNPs of pharmaceutical importance derive from the so-called secondary metabolism of marine organisms. When production strategies rely on marine macroorganisms, harvesting or culturing coupled with extraction procedures frequently remain the only alternative to producing these compounds on an industrial scale. Their supply can often be implemented with laboratory scale cultures for bacterial, fungal, or microalgal sources. However, a diverse approach, combining traditional methods with modern synthetic biology and biosynthesis strategies, must be considered for invertebrate MNPs, as they are usually naturally accumulated in only very small quantities. This review offers a comprehensive examination of various production strategies for MNPs, addressing the challenges related to supply, synthesis, and scalability. It also underscores recent biotechnological advancements that are likely to transform the current industrial-scale manufacturing methods for pharmaceuticals derived from marine sources.https://www.mdpi.com/1660-3397/23/2/69total synthesisaquaculturechemoenzymatic synthesisfermentationex vivo biosynthesiscell factory |
| spellingShingle | Henar Martínez Mercedes Santos Lucía Pedraza Ana M. Testera Advanced Technologies for Large Scale Supply of Marine Drugs Marine Drugs total synthesis aquaculture chemoenzymatic synthesis fermentation ex vivo biosynthesis cell factory |
| title | Advanced Technologies for Large Scale Supply of Marine Drugs |
| title_full | Advanced Technologies for Large Scale Supply of Marine Drugs |
| title_fullStr | Advanced Technologies for Large Scale Supply of Marine Drugs |
| title_full_unstemmed | Advanced Technologies for Large Scale Supply of Marine Drugs |
| title_short | Advanced Technologies for Large Scale Supply of Marine Drugs |
| title_sort | advanced technologies for large scale supply of marine drugs |
| topic | total synthesis aquaculture chemoenzymatic synthesis fermentation ex vivo biosynthesis cell factory |
| url | https://www.mdpi.com/1660-3397/23/2/69 |
| work_keys_str_mv | AT henarmartinez advancedtechnologiesforlargescalesupplyofmarinedrugs AT mercedessantos advancedtechnologiesforlargescalesupplyofmarinedrugs AT luciapedraza advancedtechnologiesforlargescalesupplyofmarinedrugs AT anamtestera advancedtechnologiesforlargescalesupplyofmarinedrugs |