Discovery of KRAS(G12D) selective degrader ASP3082

Discovery of KRAS(G12D) selective degrader ASP3082

Abstract Kirsten rat sarcoma viral oncogene homolog (KRAS) is one of the most frequently mutated oncogenes in multiple cancers. Multiple types of KRAS mutation are observed in various patients with cancer, and the KRAS(G12D) mutation is the most common. Although multiple covalent inhibitors of the K...

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Main Authors: Tomohiro Yoshinari, Takeyuki Nagashima, Hiroki Ishioka, Kohei Inamura, Yoshihiro Nishizono, Mamoru Tasaki, Kanako Iguchi, Atsushi Suzuki, Chikako Sato, Ayako Nakayama, Yasushi Amano, Yukihiro Tateishi, Yosuke Yamanaka, Fumio Osaki, Masayasu Yoshino, Kazuyuki Kuramoto, Tomoyoshi Imaizumi, Masahiko Hayakawa
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Communications Chemistry
Online Access:https://doi.org/10.1038/s42004-025-01662-4
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