Matrix Gla Protein – a new marker for colorectal cancer detection? A systematic review
Background. Colorectal cancer is a real public health issue, with high morbidity and severe impact on quality of life. Although mortality from this type of cancer is decreasing due to modern diagnostic and treatment methods, the understanding of its genetic and molecular mechanisms is important...
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| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-04-01
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| Series: | Journal of Mind and Medical Sciences |
| Subjects: | |
| Online Access: | https://scholar.valpo.edu/cgi/viewcontent.cgi?article=1373&context=jmms |
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| Summary: | Background. Colorectal cancer is a real public health issue, with high
morbidity and severe impact on quality of life. Although mortality from
this type of cancer is decreasing due to modern diagnostic and treatment
methods, the understanding of its genetic and molecular mechanisms is
important to develop a broader range of diagnostic and therapeutic
approaches. Genetic therapy is an important strategy in cancer treatment,
and the matrix Gla protein (MGP) gene expression has been described in
numerous studies as increased in tumour pathology. In this article, we have
summarized the currently available evidence on the connection between
MGP and colorectal cancer. Materials and Methods. Following the
PRISMA guidelines, we have searched the PubMed, ProQuest and
ScienceDirect databases for relevant published works that studied the
connection between colorectal cancer and MGP gene expression. Results.
Three relevant works were included in this systematic review. Two of these
studies have observed MGP gene overexpression in tumour cells, a result
that contradicts the third study, where the MGP gene was underexpressed.
Conclusions. The data provided by these articles is contradictory, and
therefore more studies are needed on larger sets of subjects, to fully
understand the connection between MGP and colorectal cancer. |
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| ISSN: | 2392-7674 |